Separation & Purification

Additive value: Inside GE Healthcare’s 3D printing and design lab

21-Nov-2017 By Dan Stanton

GE Healthcare opened its European Innovative Design and Advanced Manufacturing Technology Center last month. Biopharma-Reporter took a visit to Uppsala, Sweden to find out more.

GE pumping up to $350m in Swedish site to support biopharma demand

14-Nov-2017 By Dan Stanton

GE Healthcare will invest $50-70m a year until 2022 in its bioprocessing equipment and consumables site in Uppsala, Sweden.

Merck KGaA: Extensive uptake of single-use forced efficiency drive

10-Nov-2017 By Dan Stanton

Single-use demand grew so fast vendors were unable to keep up, says MilliporeSigma which has since tackled this through investments and a standardised offering.

Samsung BioLogics extends supply agreement with MilliporeSigma

08-Nov-2017 By Dan Stanton

Samsung BioLogics has extended a memorandum of understanding with MilliporeSigma for supply of single-use systems and bioprocessing raw materials.

Purolite teams with Repligen for prefilled Protein A columns

03-Nov-2017 By Dan Stanton

Purolite Life Sciences will offer its Protein A resin prefilled in Repligen’s chromatography columns through a partnership between the two firms.

Sartorius Stedim Biotech cuts guidance citing hurricane, destocking and supply problems

25-Oct-2017 By Gareth Macdonald

Sartorius Stedim Biotech (SSB) has cut its full year guidance, citing the negative impact of hurricane Maria, customer destocking and ongoing issues with a cell culture media supplier.

Univercells: 'Micro-facilities' to slash the cost of vaccine manufacture

20-Oct-2017 By Cutting the cost of vaccine manufacture, Univercells

High-density single-use bioreactors, small facilities and continuous manufacturing will cut the cost of manufacturing polio vaccines down to $0.15 per dose, says Univercells.

Amgen: Industry must look to next-generation continuous cell harvesting tech

17-Oct-2017 By Dan Stanton

Amgen says it is evaluating Pall’s Cadence Acoustic Separation as a primary cell clarification method for monoclonal antibodies.

News in Brief

MilliporeSigma opens $115m life science centre in Massachusetts

11-Oct-2017 By Staff Reporter

MilliporeSigma has cut the ribbon on a life science site in Burlington that incorporates a biomanufacturing equipment education centre.

Teva: CIP and SIP changes extended life of Protein A resin by 50%

11-Oct-2017 By Dan Stanton

Teva says it has increased the lifespan of its Protein A resin and thus reduced the cost of manufacturing monoclonal antibodies by tweaking its cleaning materials.

Biotech Week Boston

Beyond flexible: Deployable plants offer pay-as-you-go biomanufacturing, says Just

10-Oct-2017 By Dan Stanton

Faster and more flexible biomanufacturing models are necessary to reduce the cost of biologics, says Just Biotherapeutics which is building a deployable modular facility in China.

Exclusive interview from Biotech Week Boston

Balancing the up and downstream: Repligen CEO talks R&D and M&A

03-Oct-2017 By Dan Stanton

Repligen’s customer GE Healthcare opted to make its latest Protein A ligand in-house, but CEO Tony Hunt remains confident in his firm’s long-term partnerships and diversified bioprocessing offering.

Biotech Week Boston

On the roadmap again: Industry to address 'never ending' bioprocessing evolution

27-Sep-2017 By Dan Stanton

The Biophorum Operations Group (BPOG) has begun working on 11 technology development projects after publishing its first roadmap, but the bioprocessing industry’s visions are forever evolving, says Sanofi-Genzyme.

Biotech Week Boston

Brammer leans on Pall for $50m cell & gene therapy plant expansions

27-Sep-2017 By Dan Stanton

The contract development and manufacturing organisation (CDMO) has selected Pall Life Sciences as its single-use equipment partner at its sites in Florida and Massachusetts.

Biotech Week Boston

Protein A's mAb capture efficacy offsets cost, says GE launching new offering

26-Sep-2017 By Dan Stanton

GE Healthcare has launched a Protein A resin it says can improve monoclonal antibody purification capacity by up to 40% compared to its current offering.

Filling and freeze-drying drivers for $950m Cook deal says Catalent

22-Sep-2017 By Gareth Macdonald

Catalent has cited Cook’s ability to make and freeze-dry liquid drugs as major drivers for its planned takeover and said it is keen to take on the firm’s biopharma customers.

ChromaTan to develop continuous purification tech with $2.5m US FDA grant

20-Sep-2017 By Dan Stanton

ChromaTan will develop an integrated and continuous downstream purification platform through provisions in the 21st Century Cures Act to support manufacturing initiatives.

Expression yourself: Win an iPad in our bioprocessing survey

12-Sep-2017 By Dan Stanton

Is plastic fantastic? Is stainless still à la mode*? Do Chinese hamsters continue to tow the cell line? Biopharma-Reporter wants your opinions for its second annual biomanufacturing survey.

China’s 3SBio enters North American market through $290m Therapure buy

05-Sep-2017 By Dan Stanton

3SBio will leverage Therapure’s downstream purification expertise to bolster its own biologics portfolio while expanding its contract biomanufacturing business and global presence.

From vendor to tender: Thermo Fisher completes $7.2bn Patheon acquisition

30-Aug-2017 By Dan Stanton

Thermo Fisher has entered the contract development and manufacturing (CDMO) space through the acquisition of Patheon.

MilliporeSigma to buy Natrix Separations with an eye on single use

29-Aug-2017 By Gareth Macdonald

MilliporeSigma has agreed to buy chromatography membrane supplier Natrix Separations to expand its vaccine and mAb production tech offering.

Vendors optimistic for future despite slowdown in growth

18-Aug-2017 By Dan Stanton

Bioprocessing suppliers have recently expressed optimism in the sector despite a slowdown in growth, and one expert believes this will drive investment in new tech and markets.

Bioproduction bottlenecks increasing due to staff shortages, says report

16-Aug-2017 By Dan Stanton

A shortage in expertise is causing bottlenecks in the biomanufacturing space with around half of drugmakers struggling to fill processing positions, an industry report finds.

update

Hep B vaccine supply issues at Merck & Co and GSK prompt UK to prioritize access

08-Aug-2017 By Gareth Macdonald

Public Health England has reserved NHS hepatitis B vaccine stocks for people at high risk of infection, citing shortages caused by production interruptions at Merck & Co and GSK.

Repligen closes Spectrum acquisition in latest boost for filtration business

04-Aug-2017 By Dan Stanton

Filtration drove a record quarter for Repligen which says the addition of Spectrum Pharmaceuticals will further grow its bioprocessing portfolio and geographical presence.

Thermo Fisher: Modest Q2 for life sciences due to ‘lumpiness’ of bioproduction

01-Aug-2017 By Dan Stanton

Muted bioproduction technology pegged back an otherwise strong quarter, but Thermo Fisher says it expects growth will pick up again over time.

Pall: ‘More than ever, process control is a core focus area’

28-Jul-2017 By Dan Stanton

Pall Corporation has developed a control system for its single-use benchtop bioreactor and says it will continue to invest in-house for process control technologies.

Exclusive interview with CEO TH Kim

Samsung Biologics: Reducing COGS could double mammalian CMO use to 50%

25-Jul-2017 By Dan Stanton

Samsung Biologics wants Big Pharma to up biomanufacturing outsourcing and says lessons learned from the semiconductor industry will give it the advantage in the CMO space.

EC says Merck and Sigma-Aldrich broke M&A procedures and could face $170m fine

06-Jul-2017 By Gareth Macdonald

German Merck and Sigma-Aldrich broke EU merger procedures and could face a fine equivalent to 1% of the combined firm's annual revenue according to the European Commission

Repligen CEO says Spectrum acquisition fills gap in bioprocessing product line

27-Jun-2017 By Flora Southey

Repligen Corporation has announced it will acquire filtration-focused Spectrum Pharmaceuticals for approximately $350m (€312m).

Protein A resin maker teams on continuous and column-free chromatography tech

23-Jun-2017 By Dan Stanton

ChromaTan will incorporate Purolite’s Protein A beads into its continuous platform in a move the firms say will up productivity by 15 times over conventional batch chromatography.

Thermo Fisher opens single-use tech testing centre in UK

14-Jun-2017 By Gareth Macdonald

Thermo Fisher has opened a UK test centre to allow biopharmaceutical industry customers to test single-use production technologies.

Roche accused of charging too much for Herceptin in South Africa

13-Jun-2017 By Gareth Macdonald

Roche has been accused of charging too much for its breast cancer drug trastuzumab by South African competition authorities.

Shire using Baxalta network to bring 30% Cinryze production in-house

05-May-2017 By Dan Stanton

Shire has begun adding capability within its own network to manufacture the Hereditary Angioedema (HAE) product Cinryze, currently being made by Dutch CMO Sanquin.

BPI EUROPE 2017

Continuous chromatography and single-use filtration at BPI Europe

03-May-2017 By Dan Stanton

Pall Corporation, GE Healthcare and LEWA Process Technologies showed off their latest downstream offerings to Biopharma-Reporter in Amsterdam last week.

Filtration is a ‘high value process at a marginal cost,’ says Danaher

25-Apr-2017 By Dan Stanton

Danaher reported mid-single-digit growth from its bioprocessing subsidiary Pall Life Science and expects a continued trajectory to support Biopharma’s filtration needs.

Infographic

Hey big vendor... Is bioprocessing consolidation good for the end-user?

19-Apr-2017 By Dan Stanton

Price hikes and lack of innovation, or better buying power and end-to-end services? Experts are split on supplier M&A and its effect on biomanufacturers.

MilliporeSigma launches M-pleat pattern single-use filters

14-Apr-2017 By Dan Stanton

MilliporeSigma has launched a range of high area cartridges and single use capsules it says gives biomanufacturers greater efficiency in the filtration step.

Automation acquisitions 'capture the future of streamline production,' expert

12-Apr-2017 By Dan Stanton

There is a growing trend among vendors to integrate automation technologies into their offerings says a bioprocessing expert, as GE Healthcare invests in its partner Zenith.

Roquette aims to up its biologic reagent presence

17-Mar-2017 By Staff Reporter

Roquette says investments in packaging, documentation and testing requirements have helped the firm move into the biologics excipient and reagent space.

GE Healthcare installs purification tech at FujiFilm Diosynth site

15-Mar-2017 By Staff reporter

GE Healthcare has completed another tech installation at FujiFilm Diosynth’s biopharmaceuticals facility in Billingham, UK, integrating a single-use purification system with bioreactors it provided in 2014.

Repligen to up column production on back of ‘milestone year for chromatography’

08-Mar-2017 By Dan Stanton

Repligen will boast seven packing suites for its range of OPUS chromatography columns by the end of the month, up from two this time last year.

German affinity chromatography tech firm changes hands, changes name

08-Feb-2017 By Staff Reporter

German private equity firm UV-Cap GmbH has bought Scil Proteins and renamed the affinity chromatography tech company Navigo Proteins.

Draper looks to ultrasound and geometry to reduce CAR-T manufacturing costs

07-Feb-2017 By Dani Bancroft

The Charles Stark Draper Lab has developed two microfluidic prototypes to help make the manufacturing of cell therapies cheaper and more efficient.

GE Healthcare's 'Cell line agnostic' FlexFactory to boost Turkish biosimilars business

07-Feb-2017 By Dani Bancroft

Arven will use GE Healthcare’s FlexFactory manufacturing platform to increase capacity at its mammalian-cell based bioproduction facility in Kirklareli, Turkey.

Patented GE bioreactor bag boasts of 214m CHO cells/mL in perfusion mode

31-Jan-2017 By Dan Stanton

GE Healthcare says a new inflatable bioreactor bag configured in perfusion mode can achieve a cell density over four times that of the current industry standard.

Biopharma survey: Shortage of bioprocessing talent key threat to sector

20-Jan-2017 By Dan Stanton

Industry is struggling to find and develop skilled bioprocessing workers according to respondents to NIBRT’s biopharma trends survey.

OTCQB: PMCB

Cell-in-a-Box: PharmaCyte seeks FDA advice for inoperable cancer trial

06-Jan-2017 By Dani Bancroft

PharmaCyte has announced a pre-application meeting with the US FDA, to advise on their investigational new drug (IND) filing for a clinical trial its live cell encapsulation therapy.

US FDA delays Ocrevus decision date asking Roche for more manufacturing data

23-Dec-2016 By Gareth Macdonald

The US FDA has pushed back the review date Roche’s Ocrevus (ocrelizumab) after asking for more data on processes used to manufacture the candidate MS treatment.

Repligen adds single-use filtration tech through TangenX acquisition

20-Dec-2016 By Dan Stanton

Repligen has bought Novasep subsidiary TangenX Technology for $39m, adding single-use tangential flow filtration (TFF) cassettes to its downstream offering.