The clinical value of biologics for the treatment of many disease indications has been accompanied by phenomenal sales. By 2026, the global market for...
Altasciences | 10-May-2022
| Technical / White Paper
Microsampling significantly lessens the volume of blood and plasma/serum that is collected and analyzed to determine circulating concentrations of therapeutic...
Baxter BioPharma Solutions | 16-Feb-2022
| Technical / White Paper
The production of seasonal vaccines, such as those for influenza, presents unique challenges to manufacturers due to the necessary time constraints resulting...
Baxter BioPharma Solutions | 16-Feb-2022
| Technical / White Paper
Convenience, product differentiation, and less waste are great reasons for developing a product in a prefilled syringe. Baxter’s whitepaper describes the...
At CellCarta, we’re dedicated to working with our partners to further the limitless potential of precision medicine. Our broad technology offering is designed...
As the world grapples with the effects of ongoing health crises, the market is expanding quickly as developers shift their focus to proactive therapeutics....
Upcoming ICH Q14 Guidelines are an opportunity for Contract Service Providers to embrace enhanced approaches to method development such as Analytical Quality...
Supporting the Industry Through Scientific Staffing Solutions
Fast-paced companies within the life sciences industry require agile, scalable resourcing...
Careful product design and controlled manufacturing of culture media can enable high levels of confidence in environmental monitoring results. New Thermo...
Viral Safety for mAb: Prevent, Detect, Remove | 23-Nov-2020
| Technical / White Paper
This white paper explores the factors driving the evolution toward faster biosafety testing and describes rapid approaches for adventitious agent testing...
Viral Safety for mAb: Prevent, Detect, Remove | 16-Nov-2020
| Technical / White Paper
We have a long history of developing innovative molecular technologies for cell line characterization and lot release testing for the biopharmaceutical...
The complexity of processes to manufacture cell and gene therapy medicinal products can cause confusion around definitions of raw materials, starting materials,...
Take the Right Path Upstream with MilliporeSigma | 02-Nov-2020
| Technical / White Paper
In this technical note, we investigate the interactions between the following: The spike glycoprotein binding with ACE2, Spike glycoprotein and anti-spike...
Eppendorf for Bioprocess – Solutions that grow with you | 29-Oct-2020
| Application Note
Effective drug discovery and development relies on the availability of predictive preclinical model systems. Technologies based on human induced pluripotent...
Process development is a crucial step in viral vector manufacturing and a successful CDMO partnership can help navigate the challenges associated with...
With the current increase in development and investment, gene therapy companies will increasingly be looking to streamline the manufacture and commercialization...
Process development is a crucial step in viral vector manufacturing and a successful CDMO partnership can help navigate the challenges associated with...
The MilliporeSigma organization is dedicated to supporting your cell and gene therapy from early phase through product release. Not only does our BioReliance®...
Anion exchange chromatography is an important step for viral clearance of monoclonal antibodies. Natrix® Q chromatography membrane improves cost-efficiency....
In January 2020, the United States Food and Drug Administration (FDA) released several new or updated guidance documents pertaining to human gene therapy...
Take the Right Path Upstream with MilliporeSigma | 01-Oct-2020
| Technical / White Paper
Development of a high-producing cell line supported by a robust upstream process are critical early steps in the production of monoclonal antibodies (mAbs)....
Viral contamination is a risk for all biotechnology products. Recent studies have shown that viral retentive filtration is one of the most robust steps...
MilliporeSigma - Gene Therapy | 05-Aug-2020
| Technical / White Paper
While new modalities are generating significant excitement among patients and caregivers, cell and gene therapy manufacturers are experiencing growing...
Take the Right Path Upstream with MilliporeSigma | 05-Aug-2020
| Technical / White Paper
Upstream processes can be intensified using high cell density cryopreservation, perfused seed train or production processes with steady-state perfusion,...
Take the Right Path Upstream with MilliporeSigma | 20-Jul-2020
| Technical / White Paper
This white paper describes process modeling and compares the process economics of a conventional upstream process versus three perfused seed train alternatives...
Take the Right Path Upstream with MilliporeSigma | 20-Jul-2020
| Technical / White Paper
Strategies such as process intensification have the potential to create shorter lead times, reduce plant footprint, increase flexibility, and reduce COGs.
The pressure to shorten delivery times and reduce costs for biologics are driving an evolution in the biomanufacturing space. Many of the methods used...
Take the Right Path Upstream with MilliporeSigma | 12-May-2020
| Technical / White Paper
The first commercial monoclonal antibody (mAb) was approved in 1986 and today, the global market is large and growing. Reports estimate the size of the...
Viral Safety for mAb: Prevent, Detect, Remove | 12-May-2020
| Technical / White Paper
The use of animal models for the detection of adventitious agents has been a feature of biologic testing packages for many decades. However, as alternative...
Take the Right Path Upstream with MilliporeSigma | 12-May-2020
| Technical / White Paper
The preparation of media for use in biopharmaceutical processes can be complex and may carry risks that must be identified, assessed, and mitigated to...
Eppendorf for Bioprocess – Solutions that grow with you | 10-Dec-2019
| Application Note
Experimentation at small scale is crucial for the cost-efficient development of bioprocesses, which then can be transferred to larger volumes. We have...
Eppendorf for Bioprocess – Solutions that grow with you | 01-Oct-2019
| Application Note
We successfully performed microaerobic fermenta¬tion of a probiotic strain, Lactobacillus acidophilus, at a very low oxygen level, representing the natural...
Eppendorf for Bioprocess – Solutions that grow with you | 25-Jun-2019
| Application Note
Rising interest in gene therapy-based applications leads to increasing demands in scalable production systems for viral vectors. Find out how Cevec Pharmaceuticals...
Roquette Pharma Solutions | 14-Jun-2019
| Case Study
Therapeutic proteins are inherently unstable and sensitive to temperature change, shearing, shaking, solvents, ionic strength, purity, protein concentration,...
CHT XT is the newest addition to the CHT family of media. It has been designed for superior physical robustness to ensure it can be used repeatedly over...
Eppendorf for Bioprocess – Solutions that grow with you | 17-Sep-2018
| Application Note
3D cell aggregates are of great interest for applications like disease modeling and manufacturing of stem cell-based products. Read more about the cultivation...
A desperate mother in Germany urged her team of doctors to reach out to a Marken client on behalf of her two year old girl. The child was battling leukemia...
Would you like to enhance your downstream process, increase production capacity and reduce costs? This case study application note demonstrates how implementing...
Eppendorf for Bioprocess – Solutions that grow with you | 01-May-2018
| Application Note
Viral diseases like rabies, rotavirus and influenza are causing many deaths worldwide, resulting in a strong demand for more productive manufacturing techniques...
Aflibercept (Zaltrap®) is a recombinant fusion protein with complex post-translational modifications. Therefore deep understanding of biosimilar development...
Download the eBook written by Catalent experts to learn about innovative products and techniques for scale-up of complex biologics, get optimal cell culture...
The Cadence inline diafiltration (ILDF) device is designed for continuous processing, in-process buffer exchange or contaminant removal in various processes...
At Pall we have supported the water intrusion test for more than 20 years and we developed the Palltronic® AquaWIT IV system to deliver fast and simple...
