Bioreactors

Process optimization for mAb commercial manufacturing

Content provided by Catalent | 01-Jun-2023 | Product Presentation

Process characterization and validation is an important step in the product development journey and late-phase development, and it is required before transferring...

Science baked probiotic with CultureScience and Unlimited personalization with CultureSelect

Content provided by SACCO SYSTEM | 12-Apr-2023 | Product Brochure

The customer has a central role in Sacco System and we are now ready to offer our Made4You service. We can support you in the development and study of...

Trends in Biopharmaceutical Raw Material Selection

Content provided by Actylis – The Partner of Choice | 31-Jan-2023 | Business Advice

Join us as our in-house experts, along with Cecile Bellamy from Pfizer, discuss current and future trends in biopharmaceutical raw material selection.

eBook: mRNA prospects and scale-up solutions

Content provided by Thermo Fisher Scientific - Biosciences | 01-Jan-2023 | Insight Guide

This mRNA eBook was created by Thermo Fisher Scientific, in collaboration with Genetic Engineering & Biotechnology News (GEN), to provide you with...

Liposomal and Nanoparticle Technology

Content provided by Pfizer CentreOne | 18-Nov-2022 | White Paper

Medical science is continuously searching for better ways to administer drugs into the body and to maximize the therapeutic effectiveness of the drugs...

Discover the world of upstream bioprocessing

Content provided by Eppendorf Bioprocess Solutions | 07-Sep-2022 | White Paper

A must-read for all bioprocess scientists: This bundle of four ebooks created by Eppendorf guides you through the world of upstream bioprocessing.

Tools for Confident Environmental Monitoring in the Pharmaceutical Industry

Recorded the 06-Oct-2021 | Webinar

Careful product design and controlled manufacturing of culture media can enable high levels of confidence in environmental monitoring results. New Thermo...

Manufacturing of hiPSC-Derived Cardiomyocytes

Content provided by Eppendorf Bioprocess Solutions | 29-Oct-2020 | Application Note

Effective drug discovery and development relies on the availability of predictive preclinical model systems. Technologies based on human induced pluripotent...

A Cost Analysis and Evaluation of Perfused Seed Train Scenarios Through Process Modeling

Content provided by Take the Right Path Upstream with MilliporeSigma | 20-Jul-2020 | White Paper

This white paper describes process modeling and compares the process economics of a conventional upstream process versus three perfused seed train alternatives...

Seed Train Intensification Using High Cell Density Cryopreservation and Specially-designed Expansion Medium

Content provided by Take the Right Path Upstream with MilliporeSigma | 20-Jul-2020 | White Paper

Strategies such as process intensification have the potential to create shorter lead times, reduce plant footprint, increase flexibility, and reduce COGs.

Perfusion Using an ATF Cell Retention Device

Content provided by Eppendorf Bioprocess Solutions | 10-Dec-2019 | Application Note

Experimentation at small scale is crucial for the cost-efficient development of bioprocesses, which then can be transferred to larger volumes. We have...

Microaerobic Fermentation of Lactobacillus acidophilus

Content provided by Eppendorf Bioprocess Solutions | 01-Oct-2019 | Application Note

We successfully performed microaerobic fermenta¬tion of a probiotic strain, Lactobacillus acidophilus, at a very low oxygen level, representing the natural...

rAAV Production in BioBLU® Single-Use Vessels

Content provided by Eppendorf Bioprocess Solutions | 25-Jun-2019 | Application Note

Rising interest in gene therapy-based applications leads to increasing demands in scalable production systems for viral vectors. Find out how Cevec Pharmaceuticals...

Learn more about KLEPTOSE® BioPharma for your protein stability challenges

Content provided by Roquette Pharma Solutions | 14-Jun-2019 | Case Study

Therapeutic proteins are inherently unstable and sensitive to temperature change, shearing, shaking, solvents, ionic strength, purity, protein concentration,...

Small-Scale Cell Culture Perfusion Process

Content provided by Eppendorf Bioprocess Solutions | 29-Mar-2019 | Application Note

Perfusion cell culture processes promise advantages for industrial bioprocessing, like saving space, increasing volumetric productivity, achieving more...

Removing Aggregates of an Acidic Monoclonal Antibody

Content provided by Bio-Rad Laboratories | 22-Oct-2018 | White Paper

CHT Ceramic Hydroxyapatite Media/Resins are known as the industry gold standard for
impurity removal during monoclonal antibody (mAb) purification....

Single-Step Influenza and Dengue Virus Purification

Content provided by Bio-Rad Laboratories | 08-Oct-2018 | Application Note

CHT XT is the newest addition to the CHT family of media. It has been designed for superior physical robustness to ensure it can be used repeatedly over...

Cultivation of 3D Cell Aggregates in Perfusion

Content provided by Eppendorf Bioprocess Solutions | 17-Sep-2018 | Application Note

3D cell aggregates are of great interest for applications like disease modeling and manufacturing of stem cell-based products. Read more about the cultivation...

Downstream Purification of Large Biomolecules

Content provided by Bio-Rad Laboratories | 17-Sep-2018 | Research Study

Our newest strong anion exchange resin provides both high binding capacity and
high recovery, even at high flow rates. A rigid bead complete with...

Guide to cell harvesting using Pall technology

Content provided by Pall Biotech | 20-Feb-2018 | White Paper

Accelerate Your Process Development. Your technology selection guide for the clarification of mAb processes.

Discover Fast and Simple Water Intrusion Testing

Content provided by Pall Biotech | 13-Nov-2017 | Application Note

At Pall we have supported the water intrusion test for more than 20 years and we developed the Palltronic® AquaWIT IV system to deliver fast and simple...

Survey Report: State of the global biomanufacturing and bioprocessing industry 2017

Content provided by William Reed | 19-Oct-2017 | Research Study

In September 2017, BioPharma-Reporter.com conducted its second annual ‘state of the industry’ survey on its user base of biopharmaceutical industry professionals....

An Innovative Design for Single-use Bioreactors

Content provided by Pall Biotech | 01-Jun-2017 | White Paper

For many years cylindrical stainless steel tanks have been used in biopharmaceutical production.The primary reason for the cylindrical shape was that it...

Engineering Performance: Single-Use Bioreactor

Content provided by Pall Biotech | 01-May-2017 | Application Note

Single-use bioreactors have only been cylindrical in design, until now. The Allegro™ STR single-use, stirred tank bioreactor provides advantages over the...

Automatic Fermentation with Auto Culture Mode

Content provided by Eppendorf Bioprocess Solutions | 10-Apr-2017 | Application Note

The Auto Culture modes, standard on the Eppendorf BioFlo® 120 bioprocess control station, offer push-button automatic process control for some of the most...

Micro-Matrix: a scale down system for lab scale microbial cultures

Content provided by Applikon Biotechnology | 24-Oct-2016 | White Paper

Biological product engineering relies on selecting the best performing microbial strain and finding optimal culture conditions. The screening for these...

Optimize your growth conditions in micro-bioreactors

Content provided by Applikon Biotechnology | 19-Sep-2016 | Research Study

The micro-Matrix allows rapid screening of large number of organisms and optimize media conditions. Individual and continuous measurement and control of...

Manufacturing Recombinant Protein Therapeutics under Cost Constraints

Content provided by Rentschler Biotechnologie GmbH | 16-Jun-2016 | Product Presentation

Therapeutic proteins such as monoclonal antibodies and fusion proteins represent one of the fastest growing segments in the drug pipeline, which puts pressure...

Survey Report: State of the Biopharmaceutical Industry 2016

Content provided by William Reed | 14-Jun-2016 | Insight Guide

In May 2016, BioPharma-Reporter conducted its inaugural ‘state of the industry’ survey. The key objective of the poll was to gauge views about the current...

Bioreactor based engineering of large-scale cartilage grafts for joint resurfacing

Content provided by Applikon Biotechnology | 29-Feb-2016 | White Paper

Apart from partial or total joint replacement, no surgical procedure is currently available to treat large and deep cartilage defects associated with advanced...

Screening for growth conditions using micro-Matrix

Content provided by Applikon Biotechnology | 12-Oct-2015 | Case Study

Screening of large number of cell lines, specific media or target drug could be tedious and expensive work. This is also the case for the characterization...

New White Paper: Multiplexing in Bioanalysis

Content provided by SGS Life Science Services | 28-Sep-2015 | White Paper

SGS scientists have validated a multiplex, bead-based immunoassay which determines nine cytokines simultaneously per sample, resulting in savings in costs,...

Getting Big Benefits from Small Components

Content provided by AdvantaPure® | 14-Sep-2015 | White Paper

Like a chain, a biopharma transfer system depends on each of its links being strong enough to protect the integrity of the materials being transferred...

Expansion of Mesenchymal Stem Cells in Single-Use Bioreactors

Content provided by Eppendorf Bioprocess Solutions | 24-Aug-2015 | Research Study

Stem cell-based regenerative medicine has great potential to advance the therapeutic treatment of human diseases. Among the various stem cell platforms,...

Accurate control of Glucose and Lactate in bioreactors

Content provided by Applikon Biotechnology | 10-Aug-2015 | Research Study

The Applikon BioSenz is a unique measuring device specifically developed for measuring & controlling glucose and lactate in bioreactors. Patented heat-flux...

Efficient bioprocess development

Content provided by Eppendorf Bioprocess Solutions | 15-Jun-2015 | Application Note

Bioprocess development requires software that not only monitors and controls process runs, but also integrates design, execution and evaluation of experiments....

Centrifuges designed to simplify performance

Content provided by Thermo Fisher Scientific | 27-Apr-2015 | Infographic

Centrifuges are an integral part of almost every lab. However the set-up of a centrifuge run can be extremely time consuming. Large rotors require assistance...

RAM Resonance Acoustic Mixer, Shaken Not Stirred

Content provided by Applikon Biotechnology | 20-Apr-2015 | White Paper

The RAM® bench top biological mixer utilizes Resonant Acoustic® technology that applies low-frequency, high-intensity acoustic energy to agitate microbial...

Generating scalable results in micro-bioreactors

Content provided by Applikon Biotechnology | 14-Apr-2015 | White Paper

Micro-bioreactors are gaining market share in R&D laboratories. Common applications are strain selection, medium optimization and optimization of cultivation...

BioSep, Scalable & gentle cell culture perfusion

Content provided by Applikon Biotechnology | 09-Apr-2015 | White Paper

The Applikon BioSep system is a unique, cell retention device for high-density perfusion processes. BioSep is the ultimate tool for cell culture perfusion...

Single-use systems designed for your workflow

Content provided by Thermo Fisher Scientific | 01-Apr-2015 | White Paper

Fluid transfer is an integral part of any biopharmaceutical manufacturing process, and one that can prove challenging. Choosing a customized, single-use...

Generating scalable results in micro-bioreactors

Content provided by Applikon Biotechnology | 23-Mar-2015 | White Paper

Micro-bioreactors are gaining market share in R&D laboratories. Common applications are strain selection, medium optimization and optimization of cultivation...

The whole blood assay: Detection of broad spectrum of pyrogens & examples of medical device testing

Merck KGaA, Darmstadt, Germany | Recorded the 09-Apr-2015 | Webinar

Pyrogens in pharmaceuticals, medical devices, biotherapeutics and cosmetics can cause fevers in humans and are potentially life-threatening. Yet standard...

GPEx® Expression System Increased Production of Pritumumab in a CHO Cell Line

In this case study poster presentation, the GPEx®  mammalian expression technology was used for the production of Pritumumab and compared to human hybridoma...

Customized Biosimilarity Analytical Testing from Catalent

Content provided by Catalent | 09-Feb-2015 | White Paper

Assessment of biosimilar molecules requires an orthogonal analytical approach.  Any one particular analytical technique is not able to fully define the...

Quantitative Analysis of Bioprocess Engineering Parameters

Content provided by Eppendorf Bioprocess Solutions | 02-Feb-2015 | Data Sheet

This poster characterizes the capabilities of the new Eppendorf BioFlo® 320 bioprocess control station in terms of key process parameters including oxygen...

Accelerated Biosimilar Development From Catalent Biologics

Despite the controversy surrounding the thicket of regulatory requirements for approval of biosimilars in various markets, regulatory agencies and governments...

Fermentation Using Single-Use Bioreactors: A Comparative Study

Content provided by Eppendorf Bioprocess Solutions | 18-Nov-2014 | Application Note

In recent years single-use bioreactors gained more and more importance in mammalian cell culture. With the new line of BioBLU f rigid wall, stirred-tank...

The scalable solution to consistent cell culture

Content provided by Thermo Fisher Scientific | 07-Nov-2014 | Case Study

From research through to full scale bioproduction, you need a system that delivers reliable results, makes effective use of space and is easy to scale...

Bacteria Welcome – BioBLU® f Single-Use Vessels

Content provided by Eppendorf Bioprocess Solutions | 15-Sep-2014 | Data Sheet

The BioBLU 0.3f and BioBLU 1f Single-Use Vessels allow microbial process development at the highest level. These rigid wall stirred-tank single-use vessels...