Separation & Purification

GE Healthcare and G-CON create platform for advanced therapy production

24-Jan-2019 By Ben Hargreaves

GE Healthcare and G-CON have combined capabilities to offer drug developers ‘readily deployable’ manufacturing platforms for cell therapies and viral vectors.

Boehringer expands commercial biologics production capacity in China

22-Jan-2019 By Ben Hargreaves

Boehringer will increase its capacity for commercial manufacturing of biologics at its Shanghai, China, facility.

DuPont excipient could ‘double to triple’ biologics’ shelf life

14-Jan-2019 By Ben Hargreaves

DuPont has developed an excipient that could be more efficient and stable than current products on the market.

Cambrex continues build-out at former PharmaCore site with $1m investment

11-Dec-2018 By Melissa Fassbender

Cambrex is investing $1m at its High Point, NC-based site, marking the most recent in a series of investments which will see the addition of 1,300 square feet and 15 new employees.

Biotage acquires Phynexus in $21.5m deal

11-Dec-2018 By Maggie Lynch

Biotage will add PhyNexus’ platform for higher throughput purification at lab-scale.

Tech focus: Making waves with acoustic separation in cell processing

06-Dec-2018 By Ben Hargreaves

FloDesign Sonics is using ‘acoustophoresis’ to address challenges in cell therapy manufacture.

GE to open fibre-based chromatography facility in UK

27-Nov-2018 By Flora Southey

The Stevenage facility will produce a fibre-based purification platform for the manufacture of biopharmaceuticals, gene therapies and viral vectors.

Q&A

UK cell and gene therapy ecosystem ‘second to none’

26-Nov-2018 By Ben Hargreaves

The UK has a ‘rich and vibrant’ advanced therapeutic manufacturing sector well placed to attract companies post-Brexit, says Keith Thompson, CEO of CGTC.

UK invests to streamline manufacture of next-gen medicine

23-Nov-2018 By Ben Hargreaves

Funding of £7.3m will be provided across three initiatives, with the long-term aim of providing patients with access to cell and gene therapies at a faster rate.

Astellas invests $256m in cell therapy manufacturing buildout

07-Nov-2018 By Ben Hargreaves

The company will construct two facilities in Japan and relocate its regenerative medicine facility in the US.

CAR-T manufacture ‘where mAbs were in the early 1990s’, says bluebird CTMO

05-Nov-2018 By Ben Hargreaves

With cell and gene therapies developing at a rapid pace, it leaves significant questions as to how manufacturing processes are keeping up.

Lonza invests in ‘game-changer’ automated cell therapy manufacture

31-Oct-2018 By Ben Hargreaves

After a three-year partnership, Lonza pulled the trigger on acquiring a controlling stake of Octane Biotech and their jointly developed Cocoon system.

Avid expansion to triple process development capacity, says CEO

25-Oct-2018 By Ben Hargreaves

Avid continues its transition to a fully-fledged CDMO by transforming its process development capabilities with new lab space.

Shire opens $1.2bn, six-years-in-the-making facility

23-Oct-2018 By Ben Hargreaves

Shire’s immune globulin infusion-producing facility will increase the company plasma manufacturing capacity by one third.

BIA Bioscience Forum

Four major barriers to efficient cell & gene manufacture

22-Oct-2018 By Ben Hargreaves

BIA’s Bioscience Forum brought together four experts on cell and gene manufacture to discuss what difficulties are being faced in the industry and how they are reacting to them.

Berkeley Lights looks to CAR-T manufacture after securing $95m investment

19-Oct-2018 By Ben Hargreaves

This week Berkeley announced it had tied up a financing round and signed a cell line development deal with Selexis.

Purolite opens 100,000L agarose plant in Wales

28-Sep-2018 By Flora Southey

Purolite Life Sciences’ new agarose manufacturing plant will supply chromatography resins up to 70% cheaper than GE’s offerings, says executive.

NEWS IN BRIEF

BIA Separations adds upstream processing facility

28-Sep-2018 By Ben Hargreaves

BIA Separations has completed work on an additional upstream processing laboratory in Ajdovščina, Slovenia.

Lonza invests $418m in two biomanufacturing solutions

21-Sep-2018 By Ben Hargreaves

Lonza announced it would invest in two new “Ibex Solutions”, which offer manufacturing capabilities to biotechs developing antibody therapies.

BIOTECH WEEK BOSTON

3M aims to clean up with updated purifier product

12-Sep-2018 By Ben Hargreaves

3M used the platform of Biotech Week Boston to discuss its updated Emphaze AEX Hybrid Purifier product.

BIOTECH WEEK BOSTON

MilliporeSigma claims ‘first-of-its-kind’ resin improves efficiency across the board

11-Sep-2018 By Ben Hargreaves

MilliporeSigma used Biotech Week Boston to discuss the release of its Eshmuno CP-FT resin and how it can improve downstream efficiency.

Novasep launches Merck-tested BioSC Pilot for batch and continuous chromatography

26-Jun-2018 By Flora Southey

Novasep has launched a downstream processing tool that combines batch and continuous chromatography for monoclonal antibodies, recombinant proteins and blood factors.

mAb developer Oncobiologics launches CDMO business

15-Jun-2018 By Melissa Fassbender

Oncobiologics has launched a CDMO business to provide mAb development and manufacturing capabilities in a small biotech company setting, says CFO.

UK invests in cell and gene therapy workforce to prepare for commercial products

29-May-2018 By Nick Taylor

The UK is investing £3m ($4m) to build a workforce capable of delivering cell and gene therapies to patients at commercial scales.

ADC Bio’s $1.5m investment to boost antibody-drug conjugate manufacturing

01-May-2018 By Flora Southey

ADC Bio has announced receipt of a £1.14m investment it says will help reduce antibody-drug conjugate manufacturing time and costs.

Pall and Artesyn Biosolutions team to industrialize single-use tech

18-Apr-2018 By Melissa Fassbender

Pall Corporation and Artesyn Biosolutions will co-develop clinical to commercial-scale solutions for single-use automated bioprocessing systems.

Bio-Separation: Our outgoing editor looks back over 5 years

13-Apr-2018 By Dan Stanton

Biopharma-Reporter editor Dan Stanton is finally packing his buffer bag and moving upstream.

Sanofi: €350m vaccine investment part of ‘digital factory’ ambition

13-Apr-2018 By Dan Stanton

A new vaccine manufacturing facility in Toronto, Canada will boast single-use tech and closed continuous process to help improve productivity and performance, Sanofi says.

Stellar ups aquaculture on demand for limpet protein used in vaccine production

11-Apr-2018 By Dan Stanton

Demand for a protein produced from a marine mollusk used as a carrier molecule in therapeutic vaccines has driven Stellar Biotech to expand a facility in LA.

MilliporeSigma: Filling gaps in continuous bioprocessing will lower COGS

10-Apr-2018 By Dan Stanton

Vendors can help address technology gaps but industry must look to collaborations and internal development to create fully continuous bioprocesses, says MilliporeSigma.

Bioprocessing overlap: Taking lessons from small molecule makers

03-Apr-2018 By Dan Stanton

Process control, quality management and training operators are areas where biomanufacturers can learn from small molecule makers, according to preliminary results from a BioPlan Associates survey.

News in brief

ABL Europe equips viral vector plant with Sartorius single-use tech

16-Mar-2018 By Staff Reporter

Both upstream and downstream systems provided by Sartorius Stedim Biotech have been installed in ABL’s facility in Strasbourg, France.

Up to down: BIA and Nuvonis to address ‘last frontier in bioprocessing’

15-Mar-2018 By Dan Stanton

BIA Separations has teamed with Nuvonis Technologies to help vaccine and cell therapy developers tackle the transition from upstream to downstream processing.

Perfusion to fed-batch: Repligen record quarter for ATF tech

23-Feb-2018 By Dan Stanton

Repligen says the single-use version of its alternating tangential flow (ATF) platform is helping the firm capture a larger share of the fed-batch bioreactor marketplace.

Concurrent purification approach could cut ADC manufacture by 25%, ADC Bio

16-Feb-2018 By Dan Stanton

ADC Bio has developed a concurrent conjugation and antibody purification process, not reliant on Protein A capture resin.

MSD repurposing dormant Irish site and hiring 350 to support Keytruda

14-Feb-2018 By Dan Stanton

Merck Sharp & Dohme (MSD) plans to build a biologics facility at a former small molecule manufacturing site in Swords, Ireland, which it closed last year.

Correction

Repligen adding former Motorola plant in MA to filtration footprint

13-Feb-2018 By Dan Stanton

Repligen has leased a 64,000 square-foot facility in Massachusetts to where it will transfer production of its TangenX filtration products .

Waters launches LC platform-neutral bioseparations system

06-Feb-2018 By Staff Reporter

Waters Corporation says its latest bioseparations system can drive cost-savings through reduced solvent volumes and decreased run times.

Pall the ‘stand-out’ in Danaher’s life sciences Q4 results

31-Jan-2018 By Staff Reporter

Pall Corporation reported its best quarterly growth since its acquisition by Danaher in 2015.

Sanofi expanding Fabrazyme plant in MA

31-Jan-2018 By Dan Stanton

Sanofi will expand its Framingham, Massachusetts biomanufacturing facility by 14,820 square-foot to support its product portfolio.

Cellular Biomedicine Group adopts GE Healthcare tech for CAR-T therapy production

19-Jan-2018 By Gareth Macdonald

Cellular Biomedicine Group Inc (CBMG) has selected GE Healthcare’s FlexFactory technology for its CAR-T therapy production facility in Shanghai, China.

Sartorius inks deal for Quad's T cell activation tech

12-Jan-2018 By Dan Stanton

Quad Technologies has teamed with Sartorius Stedim Biotech to expand the reach of its T-cell activation reagent for cell and gene therapy production.

VC banks on CAR T through acoustic wave separation firm investment

12-Jan-2018 By Dan Stanton

Venture capital company Dynamk Capital has invested in FloDesign Sonics citing its acoustic wave separation technology’s application in the growing CAR T cell sector.

Infliximab monograph adopted by European Pharmacopoeia Commission

10-Jan-2018 By Gareth Macdonald

European Pharmacopoeia Commission has adopted the first monograph for a monoclonal antibody and is poised to add it to the European Pharmacopoeia.

3M aims at double-digit growth in $5.5bn biopharma filtration market

20-Dec-2017 By Dan Stanton

The full integration of filtration tech company Membrana is driving double-digit growth rate for 3M’s biopharma purification business, the firm says.

PBI buys BaroFold to expand biomanufacturing offering

19-Dec-2017 By Gareth Macdonald

Pressure Biosciences Inc. (PBI) has acquired BaroFold Inc. adding protein folding technology and expanding its research services offering.

Cell Therapy Manufacturing & Gene Therapy Congress

Regulatory approvals and innovation drives: Cell therapies come of age

06-Dec-2017 By Dan Stanton

Cell therapies have reached their 'teenage years' and must now overcome processing efficiencies and quality struggles, say industry delegates.

GE Healthcare buys nanofibre purification tech firm Puridify

28-Nov-2017 By Dan Stanton

GE says it will continue to invest in Puridify’s early-stage FibroSelect technology to bring it to full commercialisation.

News in Brief

Stax to the mAx? Pall launches single-use mAb harvesting tech

22-Nov-2017 By Staff Reporter

Pall Corporation has launched a monoclonal antibody clarification platform without centrifugation or process additives to support cell cultures of up to 2,000L.

ADC Bio: Industry unprepared for aggregation risk of next-generation ADCs

22-Nov-2017 By Dan Stanton

Antibody-drug conjugate (ADC) developers are at risk of aggregation issues caused by the hydrophobic nature of next-generation linker-payloads, says ADC Bio.