AbbVie enters $90m agreement to develop multiple myeloma immunotherapy

By Maggie Lynch contact

- Last updated on GMT

(Image: Getty/undefined undefined)
(Image: Getty/undefined undefined)

Related tags: Immunotherapy, AbbVie, Multiple myeloma, Bispecific antibodies, Antibody, Biologics, Immune system

AbbVie and Teneobio enter an agreement to develop and commercialize an immunotherapeutic for the treatment of multiple myeloma using the latter’s proprietary anti-CD3 platform.

Through the agreement, the companies will use Teneobio’s anti-CD3 platform to develop TNB-383B, a B-cell maturation antigen (BCMA) targeting immunotherapy treatment.

TNB-383B is a bispecific antibody that targets both BCMA and CD3, using the body’s immune system to target and kill the surface protein BCMA on tumor cells. BCMA proteins support the survival of multiple myeloma cells.

Per the agreement, TeneoOne, an affiliate of Teneobio focused on developing biologics, will receive an upfront payment of $90m (€79.8m) to continue developing TNB-383B through Phase I clinical trials.

AbbVie will hold the right to acquire TeneoBio’s biologic development sect TeneoOne, for global development and commercialization of the therapy candidate.

Mohit Trikha, VP and head of oncology early development at AbbVie, said in a statement, "Multiple myeloma is one of the most common hematological cancers and an area of significant medical need. Teneobio's novel approach to T-cell redirection with TNB-383B has the potential to be a treatment option that may offer new hope for myeloma patients."

Teneobio is expected to begin the clinical program for TNB-383B in the first half of 2019.

Therapies used to target BCMA proteins for the treatment of multiple myeloma have been developed before, but many of these drug candidates​ were chimeric antigen receptor (CAR) T-cell therapies. Bluebird Bio and Celgene entered an agreement​ in March 2018 to co-develop a BCMA CAR-T cell therapy for the treatment of multiple myeloma.

Related news

Show more

Related products

dPCR Case Study

dPCR Case Study

CellCarta | 08-Aug-2022 | Case Study

Streamline your adoptive cell therapy program with digital PCR. Our team has a unique expertise in digital and quantitative PCR to support you in ensuring...

Consideration and Options for Prefilled Syringes

Consideration and Options for Prefilled Syringes

Baxter BioPharma Solutions | 16-Feb-2022 | Technical / White Paper

Convenience, product differentiation, and less waste are great reasons for developing a product in a prefilled syringe. Baxter’s whitepaper describes the...

Seasonal Vaccine Manufacturing

Seasonal Vaccine Manufacturing

Baxter BioPharma Solutions | 16-Feb-2022 | Technical / White Paper

The production of seasonal vaccines, such as those for influenza, presents unique challenges to manufacturers due to the necessary time constraints resulting...

Partner with Experts in Precision Medicine

Partner with Experts in Precision Medicine

CellCarta | 17-Jan-2022 | Product Brochure

At CellCarta, we’re dedicated to working with our partners to further the limitless potential of precision medicine. Our broad technology offering is designed...

Related suppliers

Follow us

Products

View more

Webinars