Separation & Purification

Process optimization for mAb commercial manufacturing

Content provided by Catalent | 01-Jun-2023 | Product Presentation

Process characterization and validation is an important step in the product development journey and late-phase development, and it is required before transferring...

Low recovery for pH-sensitive antibodies and Fc-formats?

Content provided by Purolite Corporation | 31-Mar-2023 | Data Sheet

Optimize your protein A step with a novel resin for elution at higher pH levels.

Connectivity & Integration in Biomanufacturing

Content provided by Wheeler Bio | 17-Nov-2022 | White Paper

As the Pharma 4.0 initiative sets a new industry paradigm, more biomanufacturing companies are asking how they can design and build facilities that apply...

GMP manufacturing of buffers and liquid blends

Content provided by Actylis – The Partner of Choice | 16-Nov-2022 | White Paper

Actylis manufactures buffers, process solutions, cleaning solutions, Water for Injection (WFI) for further processing, and custom liquid blends in compliance...

Custom manufacturing of protease inhibitor PMSF

Content provided by Actylis – The Partner of Choice | 09-Nov-2022 | White Paper

By combining 75+ years of manufacturing and sourcing expertise, Actylis provides a wide portfolio of GMP ingredients to the pharma & biopharma market,...

Scalability, Quality, and Speed with Transposons

Content provided by Wheeler Bio | 20-Oct-2022 | White Paper

To solve for the significant bottlenecks often presented by conventional cell line development processes, this article discusses how Wheeler Bio is leveraging...

Accelerating Time to IND with Pharma 4.0

Content provided by Wheeler Bio | 22-Sep-2022 | White Paper

The future of the biopharmaceutical industry hinges on its adoption of 21st-century digital tools and automation.

High quality excipients and formulation support

Content provided by Roquette Pharma Solutions | 09-Nov-2021 | Product Brochure

As the world grapples with the effects of ongoing health crises, the market is expanding quickly as developers shift their focus to proactive therapeutics....

Tools for Confident Environmental Monitoring in the Pharmaceutical Industry

Recorded the 06-Oct-2021 | Webinar

Careful product design and controlled manufacturing of culture media can enable high levels of confidence in environmental monitoring results. New Thermo...

Protect your bulk filtration and dispense step

Content provided by Parker Bioscience Filtration | 20-Jan-2020 | Data Sheet

Does your process need greater protection when the value of your product is at its highest?

At the bulk filtration and container fill stage,...

Removing Aggregates of an Acidic Monoclonal Antibody

Content provided by Bio-Rad Laboratories | 22-Oct-2018 | White Paper

CHT Ceramic Hydroxyapatite Media/Resins are known as the industry gold standard for
impurity removal during monoclonal antibody (mAb) purification....

Single-Step Influenza and Dengue Virus Purification

Content provided by Bio-Rad Laboratories | 08-Oct-2018 | Application Note

CHT XT is the newest addition to the CHT family of media. It has been designed for superior physical robustness to ensure it can be used repeatedly over...

Downstream Purification of Large Biomolecules

Content provided by Bio-Rad Laboratories | 17-Sep-2018 | Research Study

Our newest strong anion exchange resin provides both high binding capacity and
high recovery, even at high flow rates. A rigid bead complete with...

Inline concentration improves process economics

Content provided by Pall Biotech | 15-Jun-2018 | Case Study

Would you like to enhance your downstream process, increase production capacity and reduce costs? This case study application note demonstrates how implementing...

Guide to cell harvesting using Pall technology

Content provided by Pall Biotech | 20-Feb-2018 | White Paper

Accelerate Your Process Development. Your technology selection guide for the clarification of mAb processes.

Inline diafiltration enables continuous processing

Content provided by Pall Biotech | 13-Feb-2018 | Application Note

The Cadence inline diafiltration (ILDF) device is designed for continuous processing, in-process buffer exchange or contaminant removal in various processes...

Survey Report: State of the global biomanufacturing and bioprocessing industry 2017

Content provided by William Reed | 19-Oct-2017 | Research Study

In September 2017, BioPharma-Reporter.com conducted its second annual ‘state of the industry’ survey on its user base of biopharmaceutical industry professionals....

A Trusted Resin Provider For Over 35 Years

Content provided by Purolite Life Sciences | 18-Sep-2017

Watch our video above to learn more about the history of Purolite Life Sciences.To discuss how we can assist your journey to process excellence, please...

How to get reproducible DNA amplification

Content provided by Eppendorf Bioprocess Solutions | 27-Jun-2017 | Infographic

DNA concentration, mastermix preparation, temperature management: Doing PCR like a pro can be more complex than it seems.The Eppendorf infographic helps...

Scale-Up of Multicolumn Chromatography

Content provided by Pall Biotech | 21-Jun-2017 | Application Note

The Cadence™ BioSMB platform from Pall Life Sciences is the first disposable flow path, continuous multicolumn chromatography solution that is fully scalable...

Method for Optimizing mAb Polishing Using CMM HyperCel™ Mixed-Mode Cation Exchanger

Content provided by Pall Biotech | 12-Jun-2017 | Application Note

mAbs are produced for a number of therapeutic applications. However, mAbs are not a homogeneous family of products. Each mAb is unique, based on its isoelectric...

Guide to Continuous Bioprocessing

Content provided by Pall Biotech | 11-May-2017 | Data Sheet

Continuous manufacturing has been established in several processing industries for many years, providing many benefits over batch manufacturing. Until...

Robust Virus Retention with Pressure Interruptions

Content provided by Pall Biotech | 17-Oct-2016 | Application Note

Virus filtration is a vital part of the viral clearance strategy in bioprocesses. In filtration, size exclusion mechanisms are orthogonal to other inactivation...

Continuous mAb Chromatography Process Optimization

Content provided by Pall Biotech | 25-Jul-2016 | White Paper

Learn the advantages of transferring from single column to continuous chromatography processes with connected unit operations. This poster titled “Demonstration...

Survey Report: State of the Biopharmaceutical Industry 2016

Content provided by William Reed | 14-Jun-2016 | Insight Guide

In May 2016, BioPharma-Reporter conducted its inaugural ‘state of the industry’ survey. The key objective of the poll was to gauge views about the current...

Capture the Most From Your Suspension Cell Cultures

Content provided by Applikon Biotechnology | 06-Jun-2016

The iLine F microscope changes the way you count your suspension cells. It continuously and automatically analyzes images of your cells, discriminates...

Single-Pass TFF and the New Era of Bioprocessing

Content provided by Pall Biotech | 18-Apr-2016 | White Paper

Learn how single-pass tangential flow filtration (SPTFF) technology is revolutionizing current and future bioprocessing platforms with its implementations...

Selecting Vent Filters For Ozonated Water Tanks

Content provided by Pall Biotech | 15-Feb-2016 | Application Note

With many pharmaceutical processes needing large water volumes, it’s vital to protect the water against contamination. Storage of purified water at a minimum...

Volume Reduction & Downstream Process Optimization

Content provided by Pall Biotech | 04-Feb-2016 | Application Note

Pall’s single-pass tangential flow filtration (SPTFF) technology provides a simple solution for continuous concentration and optimization of DSP steps....

Infographic: How to become a pipetting expert

Content provided by Eppendorf Bioprocess Solutions | 09-Nov-2015 | Infographic

Reverse pipetting, problem liquids, getting the angle right: Pipetting like a pro can be more complex than it seems. The Eppendorf infographic helps you...

Centrifuges designed to simplify performance

Content provided by Thermo Fisher Scientific | 27-Apr-2015 | Infographic

Centrifuges are an integral part of almost every lab. However the set-up of a centrifuge run can be extremely time consuming. Large rotors require assistance...

BioSep, Scalable & gentle cell culture perfusion

Content provided by Applikon Biotechnology | 09-Apr-2015 | White Paper

The Applikon BioSep system is a unique, cell retention device for high-density perfusion processes. BioSep is the ultimate tool for cell culture perfusion...

Single-use systems designed for your workflow

Content provided by Thermo Fisher Scientific | 01-Apr-2015 | White Paper

Fluid transfer is an integral part of any biopharmaceutical manufacturing process, and one that can prove challenging. Choosing a customized, single-use...

Chromatography membrane for polishing applications

Content provided by Pall | 25-Mar-2015 | Application Note

In collaboration with ProBioGen AG, Mustang Q chromatography membrane was evaluated as a polishing step following protein A affinity and cation exchange...

The whole blood assay: Detection of broad spectrum of pyrogens & examples of medical device testing

Merck KGaA, Darmstadt, Germany | Recorded the 09-Apr-2015 | Webinar

Pyrogens in pharmaceuticals, medical devices, biotherapeutics and cosmetics can cause fevers in humans and are potentially life-threatening. Yet standard...

GPEx® Expression System Increased Production of Pritumumab in a CHO Cell Line

In this case study poster presentation, the GPEx®  mammalian expression technology was used for the production of Pritumumab and compared to human hybridoma...

Customized Biosimilarity Analytical Testing from Catalent

Content provided by Catalent | 09-Feb-2015 | White Paper

Assessment of biosimilar molecules requires an orthogonal analytical approach.  Any one particular analytical technique is not able to fully define the...

Accelerated Biosimilar Development From Catalent Biologics

Despite the controversy surrounding the thicket of regulatory requirements for approval of biosimilars in various markets, regulatory agencies and governments...

Purification process optimization of Fab fragments

Content provided by Pall Biotech | 21-Jan-2015 | Application Note

Fab antibody fragments have been increasingly used for therapeutic applications. Expressed at high yield, they are very specific and lack the Fc portion...

Broad spectrum pyrogen detection according to pharmacopoeia

Content provided by Merck KGaA, Darmstadt, Germany | 02-Dec-2014 | Application Note

The Monocyte-Activation Test (MAT), which was introduced into the European Pharmacopoeia in 2010, detects pyrogens in pharmaceuticals. It covers a much...

Broad spectrum pyrogen detection

Content provided by EMD Millipore | 02-Dec-2014 | Application Note

The Monocyte-Activation Test (MAT), which was introduced into the European Pharmacopoeia in 2010, detects pyrogens in pharmaceuticals. It covers a much...

The scalable solution to consistent cell culture

Content provided by Thermo Fisher Scientific | 07-Nov-2014 | Case Study

From research through to full scale bioproduction, you need a system that delivers reliable results, makes effective use of space and is easy to scale...

Single-Use Practices for Cleanroom Fluid Transfer

Content provided by AdvantaPure® | 29-Sep-2014 | White Paper

Pharmaceutical and biopharma manufacturers must transfer fluids from room to room quickly with maximum productivity and minimal effort and expense. By...

Turning “Oh No” into “No Problem”

Content provided by World Courier | 15-Sep-2014 | White Paper

With all that’s going on in the world right now it’s vital for us all to have plans in place to deal with the unexpected. We need to be prepared individually,...

Analysis & Control of Particles in Biologics

Content provided by SGS Life Science Services | 08-Sep-2014 | White Paper

A key challenge for companies developing biologics is the control of particles in the product formulation. Regulatory authorities require information on...

Do you have spores?

Content provided by Steris: A global leader in infection prevention and contamination control | 27-May-2014 | White Paper

Trending analysis of cleanroom environmental monitoring data sometimes shows the presence of spores. These undesirable microbes must be eradicated quickly...

Developing a bioformulation stability profile

Content provided by Information not available | 27-Mar-2014 | White Paper

Rapidly identifying stable biotherapeutic formulations is critical to reducing development costs and determining a biotherapeutic's future success....

Efficient production combining smart synthesis & purification

Content provided by Novasep | 06-Sep-2013 | Case Study

Molecules reaching the market in the recent years present an ever-growing complexity. In the meantime, purity criteria are more stringent than ever to...