Cell lines

Process optimization for mAb commercial manufacturing

Content provided by Catalent | 01-Jun-2023 | Product Presentation

Process characterization and validation is an important step in the product development journey and late-phase development, and it is required before transferring...

Connectivity & Integration in Biomanufacturing

Content provided by Wheeler Bio | 17-Nov-2022 | White Paper

As the Pharma 4.0 initiative sets a new industry paradigm, more biomanufacturing companies are asking how they can design and build facilities that apply...

Scalability, Quality, and Speed with Transposons

Content provided by Wheeler Bio | 20-Oct-2022 | White Paper

To solve for the significant bottlenecks often presented by conventional cell line development processes, this article discusses how Wheeler Bio is leveraging...

Accelerating Time to IND with Pharma 4.0

Content provided by Wheeler Bio | 22-Sep-2022 | White Paper

The future of the biopharmaceutical industry hinges on its adoption of 21st-century digital tools and automation.

Discover the world of upstream bioprocessing

Content provided by Eppendorf Bioprocess Solutions | 07-Sep-2022 | White Paper

A must-read for all bioprocess scientists: This bundle of four ebooks created by Eppendorf guides you through the world of upstream bioprocessing.

Tools for Confident Environmental Monitoring in the Pharmaceutical Industry

Recorded the 06-Oct-2021 | Webinar

Careful product design and controlled manufacturing of culture media can enable high levels of confidence in environmental monitoring results. New Thermo...

How Viral Safety Testing Will Evolve

Content provided by Viral Safety for mAb: Prevent, Detect, Remove | 20-May-2020 | Event Programme

The pressure to shorten delivery times and reduce costs for biologics are driving an evolution in the biomanufacturing space. Many of the methods used...

Alternatives to in vivo assays for biosafety testing of biologics

Content provided by Viral Safety for mAb: Prevent, Detect, Remove | 12-May-2020 | White Paper

The use of animal models for the detection of adventitious agents has been a feature of biologic testing packages for many decades. However, as alternative...

rAAV Production in BioBLU® Single-Use Vessels

Content provided by Eppendorf Bioprocess Solutions | 25-Jun-2019 | Application Note

Rising interest in gene therapy-based applications leads to increasing demands in scalable production systems for viral vectors. Find out how Cevec Pharmaceuticals...

Small-Scale Cell Culture Perfusion Process

Content provided by Eppendorf Bioprocess Solutions | 29-Mar-2019 | Application Note

Perfusion cell culture processes promise advantages for industrial bioprocessing, like saving space, increasing volumetric productivity, achieving more...

Cultivation of 3D Cell Aggregates in Perfusion

Content provided by Eppendorf Bioprocess Solutions | 17-Sep-2018 | Application Note

3D cell aggregates are of great interest for applications like disease modeling and manufacturing of stem cell-based products. Read more about the cultivation...

Nifty Biosimilar

Content provided by UGA Biopharma | 13-Mar-2018 | Research Study

Aflibercept (Zaltrap®) is a recombinant fusion protein with complex post-translational modifications. Therefore deep understanding of biosimilar development...

Featured eBook: Complex Protein Production

Download the eBook written by Catalent experts to learn about innovative products and techniques for scale-up of complex biologics, get optimal cell culture...

Survey Report: State of the global biomanufacturing and bioprocessing industry 2017

Content provided by William Reed | 19-Oct-2017 | Research Study

In September 2017, BioPharma-Reporter.com conducted its second annual ‘state of the industry’ survey on its user base of biopharmaceutical industry professionals....

The Next Stage – Eppendorfs new Mastercycler X50

Content provided by Eppendorf Bioprocess Solutions | 05-Sep-2017 | Application Note

The Mastercycler X50 is Eppendorf's new PCR cycler with lots of new benefits. Not only can you heat with 10°C/s, you can also optimize two different...

Micro-Matrix: a scale down system for lab scale microbial cultures

Content provided by Applikon Biotechnology | 24-Oct-2016 | White Paper

Biological product engineering relies on selecting the best performing microbial strain and finding optimal culture conditions. The screening for these...

Optimize your growth conditions in micro-bioreactors

Content provided by Applikon Biotechnology | 19-Sep-2016 | Research Study

The micro-Matrix allows rapid screening of large number of organisms and optimize media conditions. Individual and continuous measurement and control of...

Survey Report: State of the Biopharmaceutical Industry 2016

Content provided by William Reed | 14-Jun-2016 | Insight Guide

In May 2016, BioPharma-Reporter conducted its inaugural ‘state of the industry’ survey. The key objective of the poll was to gauge views about the current...

Capture the Most From Your Suspension Cell Cultures

Content provided by Applikon Biotechnology | 06-Jun-2016

The iLine F microscope changes the way you count your suspension cells. It continuously and automatically analyzes images of your cells, discriminates...

Mycoplasma Detection in Biopharmaceuticals

Content provided by SGS Life Science Services | 16-May-2016 | White Paper

The detection of mycoplasma contamination is of utmost concern in bio-therapeutic and vaccine manufacturing. The two pharmacopeia techniques rely on the...

Screening for growth conditions using micro-Matrix

Content provided by Applikon Biotechnology | 12-Oct-2015 | Case Study

Screening of large number of cell lines, specific media or target drug could be tedious and expensive work. This is also the case for the characterization...

Centrifuges designed to simplify performance

Content provided by Thermo Fisher Scientific | 27-Apr-2015 | Infographic

Centrifuges are an integral part of almost every lab. However the set-up of a centrifuge run can be extremely time consuming. Large rotors require assistance...

RAM Resonance Acoustic Mixer, Shaken Not Stirred

Content provided by Applikon Biotechnology | 20-Apr-2015 | White Paper

The RAM® bench top biological mixer utilizes Resonant Acoustic® technology that applies low-frequency, high-intensity acoustic energy to agitate microbial...

Generating scalable results in micro-bioreactors

Content provided by Applikon Biotechnology | 14-Apr-2015 | White Paper

Micro-bioreactors are gaining market share in R&D laboratories. Common applications are strain selection, medium optimization and optimization of cultivation...

Single-use systems designed for your workflow

Content provided by Thermo Fisher Scientific | 01-Apr-2015 | White Paper

Fluid transfer is an integral part of any biopharmaceutical manufacturing process, and one that can prove challenging. Choosing a customized, single-use...

The whole blood assay: Detection of broad spectrum of pyrogens & examples of medical device testing

Merck KGaA, Darmstadt, Germany | Recorded the 09-Apr-2015 | Webinar

Pyrogens in pharmaceuticals, medical devices, biotherapeutics and cosmetics can cause fevers in humans and are potentially life-threatening. Yet standard...

GPEx® Expression System Increased Production of Pritumumab in a CHO Cell Line

In this case study poster presentation, the GPEx®  mammalian expression technology was used for the production of Pritumumab and compared to human hybridoma...

Three steps to obtain the ‘best’ recombinant CHO cell line

Content provided by Fujifilm Diosynth Biotechnologies | 23-Feb-2015 | White Paper

When developing efficient, high quality biomanufacturing processes, it is imperative that the expression system (‘host cell line’ and ‘vector’) and the...

Customized Biosimilarity Analytical Testing from Catalent

Content provided by Catalent | 09-Feb-2015 | White Paper

Assessment of biosimilar molecules requires an orthogonal analytical approach.  Any one particular analytical technique is not able to fully define the...

Accelerated Biosimilar Development From Catalent Biologics

Despite the controversy surrounding the thicket of regulatory requirements for approval of biosimilars in various markets, regulatory agencies and governments...

The scalable solution to consistent cell culture

Content provided by Thermo Fisher Scientific | 07-Nov-2014 | Case Study

From research through to full scale bioproduction, you need a system that delivers reliable results, makes effective use of space and is easy to scale...

Directed evolution creates superior CHO cell lines

Content provided by Fujifilm Diosynth Biotechnologies | 03-Nov-2014 | Data Sheet

Directed evolution is an iterative approach where selective pressure is applied to a system to identify variants with desirable characteristics, in this...

Process Transfer Excellence – Basis for a fast and successful project

Content provided by Boehringer Ingelheim Biopharmaceuticals GmbH | 30-Sep-2014 | White Paper

This whitepaper will focus on the interaction and collaboration with externals customers when transferring processes from a customer to one of Boehringer...

Ambr™ for cell line and process development

Content provided by Information not available | 14-Apr-2014 | Case Study

Requirements for rapid development have pushed process runs to a higher throughput in smaller scale. Implementation of a microbioreactor system allows...

Developing a bioformulation stability profile

Content provided by Information not available | 27-Mar-2014 | White Paper

Rapidly identifying stable biotherapeutic formulations is critical to reducing development costs and determining a biotherapeutic's future success....

Nucleic Acid Amplification Technique for Biosafety

Content provided by SGS Life Science Services | 09-Sep-2013 | White Paper

Use of cutting-edge NATs reduces the amount of time needed for development and safety testing of novel biotech products. This white paper describes specific...

How to Industrialize Stem Cell Culture Processes?

Content provided by ATMI Life Science | 25-Jun-2013 | White Paper

Learn about the scale-up of allogeneic stem cell processe, from multi-tray stacks to the Intergity® XpansionTM multiplate bioreactor. Results demonstrated...

Virus Production: From Bench to Industrial Scale

Content provided by ATMI Life Science | 25-Jun-2013 | Case Study

Discover the linear scale-up of various viral production process using the Integrity® iCELLis®, a scalable range of disposable fixed-bed bioreactors operating...