Content provided by Viral Safety for mAb: Prevent, Detect, Remove | 12-Oct-2020
| Application Note
Anion exchange chromatography is an important step for viral clearance of monoclonal antibodies. Natrix® Q chromatography membrane improves cost-efficiency....
In January 2020, the United States Food and Drug Administration (FDA) released several new or updated guidance documents pertaining to human gene therapy...
Content provided by Take the Right Path Upstream with MilliporeSigma | 01-Oct-2020
| White Paper
Development of a high-producing cell line supported by a robust upstream process are critical early steps in the production of monoclonal antibodies (mAbs)....
Viral contamination is a risk for all biotechnology products. Recent studies have shown that viral retentive filtration is one of the most robust steps...
Content provided by Take the Right Path Upstream with MilliporeSigma | 05-Aug-2020
| White Paper
Upstream processes can be intensified using high cell density cryopreservation, perfused seed train or production processes with steady-state perfusion,...
Content provided by MilliporeSigma - Gene Therapy | 05-Aug-2020
| White Paper
While new modalities are generating significant excitement among patients and caregivers, cell and gene therapy manufacturers are experiencing growing...
Content provided by Take the Right Path Upstream with MilliporeSigma | 20-Jul-2020
| White Paper
This white paper describes process modeling and compares the process economics of a conventional upstream process versus three perfused seed train alternatives...
Content provided by Take the Right Path Upstream with MilliporeSigma | 20-Jul-2020
| White Paper
Strategies such as process intensification have the potential to create shorter lead times, reduce plant footprint, increase flexibility, and reduce COGs.
Content provided by Viral Safety for mAb: Prevent, Detect, Remove | 20-May-2020
| Event Programme
The pressure to shorten delivery times and reduce costs for biologics are driving an evolution in the biomanufacturing space. Many of the methods used...
Content provided by Take the Right Path Upstream with MilliporeSigma | 12-May-2020
| White Paper
The first commercial monoclonal antibody (mAb) was approved in 1986 and today, the global market is large and growing. Reports estimate the size of the...
Content provided by Viral Safety for mAb: Prevent, Detect, Remove | 12-May-2020
| White Paper
The use of animal models for the detection of adventitious agents has been a feature of biologic testing packages for many decades. However, as alternative...
Content provided by Take the Right Path Upstream with MilliporeSigma | 12-May-2020
| White Paper
The preparation of media for use in biopharmaceutical processes can be complex and may carry risks that must be identified, assessed, and mitigated to...
Experimentation at small scale is crucial for the cost-efficient development of bioprocesses, which then can be transferred to larger volumes. We have...
We successfully performed microaerobic fermenta¬tion of a probiotic strain, Lactobacillus acidophilus, at a very low oxygen level, representing the natural...
Rising interest in gene therapy-based applications leads to increasing demands in scalable production systems for viral vectors. Find out how Cevec Pharmaceuticals...
Content provided by Roquette Pharma Solutions | 14-Jun-2019
| Case Study
Therapeutic proteins are inherently unstable and sensitive to temperature change, shearing, shaking, solvents, ionic strength, purity, protein concentration,...
Content provided by Bio-Rad Laboratories | 08-Oct-2018
| Application Note
CHT XT is the newest addition to the CHT family of media. It has been designed for superior physical robustness to ensure it can be used repeatedly over...
3D cell aggregates are of great interest for applications like disease modeling and manufacturing of stem cell-based products. Read more about the cultivation...
Content provided by Marken | 02-Jul-2018
| Case Study
A desperate mother in Germany urged her team of doctors to reach out to a Marken client on behalf of her two year old girl. The child was battling leukemia...
Content provided by Pall Biotech | 15-Jun-2018
| Case Study
Would you like to enhance your downstream process, increase production capacity and reduce costs? This case study application note demonstrates how implementing...
Viral diseases like rabies, rotavirus and influenza are causing many deaths worldwide, resulting in a strong demand for more productive manufacturing techniques...
Content provided by UGA Biopharma | 13-Mar-2018
| Research Study
Aflibercept (Zaltrap®) is a recombinant fusion protein with complex post-translational modifications. Therefore deep understanding of biosimilar development...
Download the eBook written by Catalent experts to learn about innovative products and techniques for scale-up of complex biologics, get optimal cell culture...
Content provided by Pall Biotech | 13-Feb-2018
| Application Note
The Cadence inline diafiltration (ILDF) device is designed for continuous processing, in-process buffer exchange or contaminant removal in various processes...
Content provided by Pall Biotech | 13-Nov-2017
| Application Note
At Pall we have supported the water intrusion test for more than 20 years and we developed the Palltronic® AquaWIT IV system to deliver fast and simple...
Content provided by Pall Biotech | 01-Nov-2017
| Application Note
Pall’s Supor ® buffer filters are designed for high flow rates and rapid microbial removal. This can mean dramatic reductions in buffer handling costs...
Content provided by William Reed | 19-Oct-2017
| Research Study
In September 2017, BioPharma-Reporter.com conducted its second annual ‘state of the industry’ survey on its user base of biopharmaceutical industry professionals....
Content provided by Purolite Life Sciences | 18-Sep-2017
Watch our video above to learn more about the history of Purolite Life Sciences.To discuss how we can assist your journey to process excellence, please...
The Mastercycler X50 is Eppendorf's new PCR cycler with lots of new benefits. Not only can you heat with 10°C/s, you can also optimize two different...
Content provided by Eppendorf Bioprocess Solutions | 27-Jun-2017
| Infographic
DNA concentration, mastermix preparation, temperature management: Doing PCR like a pro can be more complex than it seems.The Eppendorf infographic helps...
Content provided by Pall Biotech | 21-Jun-2017
| Application Note
The Cadence™ BioSMB platform from Pall Life Sciences is the first disposable flow path, continuous multicolumn chromatography solution that is fully scalable...
Content provided by Pall Biotech | 12-Jun-2017
| Application Note
mAbs are produced for a number of therapeutic applications. However, mAbs are not a homogeneous family of products. Each mAb is unique, based on its isoelectric...
Content provided by Pall Biotech | 01-Jun-2017
| White Paper
For many years cylindrical stainless steel tanks have been used in biopharmaceutical production.The primary reason for the cylindrical shape was that it...
Content provided by Pall Biotech | 11-May-2017
| Data Sheet
Continuous manufacturing has been established in several processing industries for many years, providing many benefits over batch manufacturing. Until...
Content provided by Pall Biotech | 01-May-2017
| Application Note
Single-use bioreactors have only been cylindrical in design, until now. The Allegro™ STR single-use, stirred tank bioreactor provides advantages over the...
The Auto Culture modes, standard on the Eppendorf BioFlo® 120 bioprocess control station, offer push-button automatic process control for some of the most...
With the rising interest in biopharmaceuticals, drug developers need to quickly understand and evaluate the binding of therapeutic antibodies to Fc receptors. ...
Content provided by Baxter BioPharma Solutions | 13-Feb-2017
| White Paper
The ultimate goal of formulation development is a stable product. In the case of a protein product, that can be defined as delivering the correct dose,...
Content provided by Catalent | 07-Nov-2016
| Infographic
With the increasing complexity of biologics and growing competition with players ranging from small start-ups to large pharma, an aggressive development...
Content provided by Applikon Biotechnology | 24-Oct-2016
| White Paper
Biological product engineering relies on selecting the best performing microbial strain and finding optimal culture conditions. The screening for these...
Content provided by Pall Biotech | 17-Oct-2016
| Application Note
Virus filtration is a vital part of the viral clearance strategy in bioprocesses. In filtration, size exclusion mechanisms are orthogonal to other inactivation...
Content provided by SGS | 19-Sep-2016
| White Paper
Regulatory authorities require head-to-head comparison at multiple levels to demonstrate that a proposed biosimilar is “similar or highly similar” to the...
Content provided by Applikon Biotechnology | 19-Sep-2016
| Research Study
The micro-Matrix allows rapid screening of large number of organisms and optimize media conditions. Individual and continuous measurement and control of...
