Technical Papers

182 Results

Microaerobic Fermentation of Lactobacillus acidophilus

Microaerobic Fermentation of Lactobacillus acidophilus

Content provided by Eppendorf Bioprocess Solutions | 01-Oct-2019 | Application Note

We successfully performed microaerobic fermenta¬tion of a probiotic strain, Lactobacillus acidophilus, at a very low oxygen level, representing the natural...

rAAV Production in BioBLU® Single-Use Vessels

rAAV Production in BioBLU® Single-Use Vessels

Content provided by Eppendorf Bioprocess Solutions | 25-Jun-2019 | Application Note

Rising interest in gene therapy-based applications leads to increasing demands in scalable production systems for viral vectors. Find out how Cevec Pharmaceuticals...

Small-Scale Cell Culture Perfusion Process

Small-Scale Cell Culture Perfusion Process

Content provided by Eppendorf Bioprocess Solutions | 29-Mar-2019 | Application Note

Perfusion cell culture processes promise advantages for industrial bioprocessing, like saving space, increasing volumetric productivity, achieving more...

Removing Aggregates of an Acidic Monoclonal Antibody

Removing Aggregates of an Acidic Monoclonal Antibody

Content provided by Bio-Rad Laboratories | 22-Oct-2018 | White Paper

CHT Ceramic Hydroxyapatite Media/Resins are known as the industry gold standard for
impurity removal during monoclonal antibody (mAb) purification....

Single-Step Influenza and Dengue Virus Purification

Single-Step Influenza and Dengue Virus Purification

Content provided by Bio-Rad Laboratories | 08-Oct-2018 | Application Note

CHT XT is the newest addition to the CHT family of media. It has been designed for superior physical robustness to ensure it can be used repeatedly over...

Cultivation of 3D Cell Aggregates in Perfusion

Cultivation of 3D Cell Aggregates in Perfusion

Content provided by Eppendorf Bioprocess Solutions | 17-Sep-2018 | Application Note

3D cell aggregates are of great interest for applications like disease modeling and manufacturing of stem cell-based products. Read more about the cultivation...

Downstream Purification of Large Biomolecules

Downstream Purification of Large Biomolecules

Content provided by Bio-Rad Laboratories | 17-Sep-2018 | Research Study

Our newest strong anion exchange resin provides both high binding capacity and
high recovery, even at high flow rates. A rigid bead complete with...

CadenceILC_610x343

Inline concentration improves process economics

Content provided by Pall Biotech | 15-Jun-2018 | Case Study

Would you like to enhance your downstream process, increase production capacity and reduce costs? This case study application note demonstrates how implementing...

Next generation single-use connector

Next generation single-use connector

Content provided by Pall Biotech | 02-May-2018 | White Paper

Assuring sterility, traceability, and quality for your single-use fluid handling.

The Kleenpak® Presto sterile connector is the only connector...

High-Density Vero Cell Perfusion Culture

High-Density Vero Cell Perfusion Culture

Content provided by Eppendorf Bioprocess Solutions | 01-May-2018 | Application Note

Viral diseases like rabies, rotavirus and influenza are causing many deaths worldwide, resulting in a strong demand for more productive manufacturing techniques...

Nifty Biosimilar

Nifty Biosimilar

Content provided by UGA Biopharma | 13-Mar-2018 | Research Study

Aflibercept (Zaltrap®) is a recombinant fusion protein with complex post-translational modifications. Therefore deep understanding of biosimilar development...

biopharma-reporter-image

Inline diafiltration enables continuous processing

Content provided by Pall Biotech | 13-Feb-2018 | Application Note

The Cadence inline diafiltration (ILDF) device is designed for continuous processing, in-process buffer exchange or contaminant removal in various processes...

Discover Fast and Simple Water Intrusion Testing

Discover Fast and Simple Water Intrusion Testing

Content provided by Pall Biotech | 13-Nov-2017 | Application Note

At Pall we have supported the water intrusion test for more than 20 years and we developed the Palltronic® AquaWIT IV system to deliver fast and simple...

Think all buffer filters are the same?

Think all buffer filters are the same?

Content provided by Pall Biotech | 01-Nov-2017 | Application Note

Pall’s Supor ® buffer filters are designed for high flow rates and rapid microbial removal. This can mean dramatic reductions in buffer handling costs...

A Trusted Resin Provider For Over 35 Years

A Trusted Resin Provider For Over 35 Years

Content provided by Purolite Life Sciences | 18-Sep-2017

Watch our video above to learn more about the history of Purolite Life Sciences.To discuss how we can assist your journey to process excellence, please...

The Next Stage – Eppendorfs new Mastercycler X50

The Next Stage – Eppendorfs new Mastercycler X50

Content provided by Eppendorf Bioprocess Solutions | 05-Sep-2017 | Application Note

The Mastercycler X50 is Eppendorf's new PCR cycler with lots of new benefits. Not only can you heat with 10°C/s, you can also optimize two different...

How to get reproducible DNA amplification

How to get reproducible DNA amplification

Content provided by Eppendorf Bioprocess Solutions | 27-Jun-2017 | Infographic

DNA concentration, mastermix preparation, temperature management: Doing PCR like a pro can be more complex than it seems.The Eppendorf infographic helps...

Scale-Up of Multicolumn Chromatography

Scale-Up of Multicolumn Chromatography

Content provided by Pall Biotech | 21-Jun-2017 | Application Note

The Cadence™ BioSMB platform from Pall Life Sciences is the first disposable flow path, continuous multicolumn chromatography solution that is fully scalable...

An Innovative Design for Single-use Bioreactors

An Innovative Design for Single-use Bioreactors

Content provided by Pall Biotech | 01-Jun-2017 | White Paper

For many years cylindrical stainless steel tanks have been used in biopharmaceutical production.The primary reason for the cylindrical shape was that it...

Guide to Continuous Bioprocessing

Guide to Continuous Bioprocessing

Content provided by Pall Biotech | 11-May-2017 | Data Sheet

Continuous manufacturing has been established in several processing industries for many years, providing many benefits over batch manufacturing. Until...

Engineering Performance: Single-Use Bioreactor

Engineering Performance: Single-Use Bioreactor

Content provided by Pall Biotech | 01-May-2017 | Application Note

Single-use bioreactors have only been cylindrical in design, until now. The Allegro™ STR single-use, stirred tank bioreactor provides advantages over the...

Automatic Fermentation with Auto Culture Mode

Automatic Fermentation with Auto Culture Mode

Content provided by Eppendorf Bioprocess Solutions | 10-Apr-2017 | Application Note

The Auto Culture modes, standard on the Eppendorf BioFlo® 120 bioprocess control station, offer push-button automatic process control for some of the most...

lyo_development

Best Practices in Formulation and Lyo Development

Content provided by Baxter BioPharma Solutions | 13-Feb-2017 | White Paper

The ultimate goal of formulation development is a stable product. In the case of a protein product, that can be defined as delivering the correct dose,...

Navigating Complex Biologics to Clinic Faster

Navigating Complex Biologics to Clinic Faster

Content provided by Catalent | 07-Nov-2016 | Infographic

With the increasing complexity of biologics and growing competition with players ranging from small start-ups to large pharma, an aggressive development...

Robust Virus Retention with Pressure Interruptions

Robust Virus Retention with Pressure Interruptions

Content provided by Pall Biotech | 17-Oct-2016 | Application Note

Virus filtration is a vital part of the viral clearance strategy in bioprocesses. In filtration, size exclusion mechanisms are orthogonal to other inactivation...

SGS-LSS

Functional Comparability of a Biosimilar

Content provided by SGS | 19-Sep-2016 | White Paper

Regulatory authorities require head-to-head comparison at multiple levels to demonstrate that a proposed biosimilar is “similar or highly similar” to the...

Optimize your growth conditions in micro-bioreactors

Optimize your growth conditions in micro-bioreactors

Content provided by Applikon Biotechnology | 19-Sep-2016 | Research Study

The micro-Matrix allows rapid screening of large number of organisms and optimize media conditions. Individual and continuous measurement and control of...

Continuous mAb Chromatography Process Optimization

Continuous mAb Chromatography Process Optimization

Content provided by Pall Biotech | 25-Jul-2016 | White Paper

Learn the advantages of transferring from single column to continuous chromatography processes with connected unit operations. This poster titled “Demonstration...

Capture the Most From Your Suspension Cell Cultures

Capture the Most From Your Suspension Cell Cultures

Content provided by Applikon Biotechnology | 06-Jun-2016

The iLine F microscope changes the way you count your suspension cells. It continuously and automatically analyzes images of your cells, discriminates...

SGS-LSS-Detection-of-Mycoplasma-in-Biopharmaceuticals-EN-16

Mycoplasma Detection in Biopharmaceuticals

Content provided by SGS Life Science Services | 16-May-2016 | White Paper

The detection of mycoplasma contamination is of utmost concern in bio-therapeutic and vaccine manufacturing. The two pharmacopeia techniques rely on the...

Single-Pass TFF and the New Era of Bioprocessing

Single-Pass TFF and the New Era of Bioprocessing

Content provided by Pall Biotech | 18-Apr-2016 | White Paper

Learn how single-pass tangential flow filtration (SPTFF) technology is revolutionizing current and future bioprocessing platforms with its implementations...

Orphan Drugs make all the difference to patients

Orphan Drugs make all the difference to patients

Content provided by World Courier | 29-Mar-2016 | White Paper

Orphan drugs, those medications that are typically produced in small quantities for limited patient populations, are growing in importance worldwide. Once...

sgs_LSS_Application

Analysis of Biomolecular Drugs using LC-MS/MS

Content provided by SGS Life Science Services | 21-Mar-2016 | White Paper

Using case studies, this white paper demonstrates the advantages and versatility of LC-MS/MS in analyzing biomolecular drugs and biomarkers at all stages...

World Courier tackles the last mile challenge

World Courier tackles the last mile challenge

Content provided by World Courier | 29-Feb-2016 | Research Study

The global pharmaceutical industry will have spent more than $10 billion on cold chain logistics in 2015, getting products and clinical trial supplies...

What do you need to know about Direct-To-Patient

What do you need to know about Direct-To-Patient

Content provided by World Courier | 22-Feb-2016 | White Paper

In the world of clinical trials, one of the greatest challenges to overcome is the recruitment and retention of qualified patients. Finding patients who...

Selecting Vent Filters For Ozonated Water Tanks

Selecting Vent Filters For Ozonated Water Tanks

Content provided by Pall Biotech | 15-Feb-2016 | Application Note

With many pharmaceutical processes needing large water volumes, it’s vital to protect the water against contamination. Storage of purified water at a minimum...

Volume Reduction & Downstream Process Optimization

Volume Reduction & Downstream Process Optimization

Content provided by Pall Biotech | 04-Feb-2016 | Application Note

Pall’s single-pass tangential flow filtration (SPTFF) technology provides a simple solution for continuous concentration and optimization of DSP steps....

How did 2015 unfold in specialty logistics?

How did 2015 unfold in specialty logistics?

Content provided by World Courier | 09-Dec-2015 | Case Study

It’s time to look back and see how our predictions for this year fared, and take another look at the things we have written about since then.We examine...