Technical / White Paper

TRANSMISSION ELECTRON MICROSCOPY IN BIOSAFETY TESTING

Format: PDF file | Document type: Technical / White Paper

SGS

TEM allows for visualization of virus particles, particle size, morphology, and intra- and extra-cellular location, both in biological fluids and in vitro. TEM methods are used extensively for the identification and enumeration of virus particles in both diagnostic virology and biological safety. TEM is recom­mended in several guidelines, specifying which materials require testing including: cell lines, culture supernatants and fermenter bulk harvests. Although relatively insensitive, TEM is a ‘catch-all’ test for viral detection which other techniques, such as in vitro ​and in vivo ​assays, or ‘specific’ molecular assays, such as qPCR, may miss.

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