Application Note

Optimization, Validation and Implementation of Retroviral Retentive Filters for Production of Adeno-Associated Virus (AAV)

Format: PDF file | Document type: Application Note

Optimization, Validation and Implementation of Retroviral Retentive Filters for Production of Adeno-Associated Virus (AAV)

Related categories: Bio-Outsourcing

Viral contamination is a risk for all biotechnology products. Recent studies have shown that viral retentive filtration is one of the most robust steps in removing all types of viruses.

In this study, we focused on the initial development process of the retroviral-retentive Viresolve® NFR filter. In order to evaluate the efficacy of the Viresolve®​ NFR filter for removal of large viruses from AGTC’s AAV vectors, a preliminary viral clearance study was performed.

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