Application Note

Inline diafiltration enables continuous processing

Format: PDF file | Document type: Application Note


The Cadence inline diafiltration (ILDF) device is designed for continuous processing, in-process buffer exchange or contaminant removal in various processes in a wide range of applications. This includes buffer exchange for final drug substance, desalting or buffer exchange before or after column chromatography, and small molecule contaminant removal. The single pump pass minimizes shear exposure, eliminates foaming/mixing concerns, and reduces the minimum working volume associated with conventional tangential flow filtration (TFF) systems operating with a recirculation loop.

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