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107 Results

Accelerating Cell Line and Process Development

Accelerating Cell Line and Process Development

Content provided by Take the Right Path Upstream with MilliporeSigma | 01-Oct-2020 | White Paper

Development of a high-producing cell line supported by a robust upstream process are critical early steps in the production of monoclonal antibodies (mAbs)....

Strategies for Upstream Intensification

Strategies for Upstream Intensification

Content provided by Take the Right Path Upstream with MilliporeSigma | 01-Sep-2020 | White Paper

The Facility of the Future represents a transformation in how biologics are developed and manufactured.

Shifting the Biomanufacturing Paradigm

Shifting the Biomanufacturing Paradigm

Content provided by Take the Right Path Upstream with MilliporeSigma | 12-May-2020 | White Paper

The first commercial monoclonal antibody (mAb) was approved in 1986 and today, the global market is large and growing. Reports estimate the size of the...

Perfusion Using an ATF Cell Retention Device

Perfusion Using an ATF Cell Retention Device

Content provided by Eppendorf Bioprocess Solutions | 10-Dec-2019 | Application Note

Experimentation at small scale is crucial for the cost-efficient development of bioprocesses, which then can be transferred to larger volumes. We have...

Microaerobic Fermentation of Lactobacillus acidophilus

Microaerobic Fermentation of Lactobacillus acidophilus

Content provided by Eppendorf Bioprocess Solutions | 01-Oct-2019 | Application Note

We successfully performed microaerobic fermenta¬tion of a probiotic strain, Lactobacillus acidophilus, at a very low oxygen level, representing the natural...

rAAV Production in BioBLU® Single-Use Vessels

rAAV Production in BioBLU® Single-Use Vessels

Content provided by Eppendorf Bioprocess Solutions | 25-Jun-2019 | Application Note

Rising interest in gene therapy-based applications leads to increasing demands in scalable production systems for viral vectors. Find out how Cevec Pharmaceuticals...

Small-Scale Cell Culture Perfusion Process

Small-Scale Cell Culture Perfusion Process

Content provided by Eppendorf Bioprocess Solutions | 29-Mar-2019 | Application Note

Perfusion cell culture processes promise advantages for industrial bioprocessing, like saving space, increasing volumetric productivity, achieving more...

Cultivation of 3D Cell Aggregates in Perfusion

Cultivation of 3D Cell Aggregates in Perfusion

Content provided by Eppendorf Bioprocess Solutions | 17-Sep-2018 | Application Note

3D cell aggregates are of great interest for applications like disease modeling and manufacturing of stem cell-based products. Read more about the cultivation...

Downstream Purification of Large Biomolecules

Downstream Purification of Large Biomolecules

Content provided by Bio-Rad Laboratories | 17-Sep-2018 | Research Study

Our newest strong anion exchange resin provides both high binding capacity and
high recovery, even at high flow rates. A rigid bead complete with...

CadenceILC_610x343

Inline concentration improves process economics

Content provided by Pall Biotech | 15-Jun-2018 | Case Study

Would you like to enhance your downstream process, increase production capacity and reduce costs? This case study application note demonstrates how implementing...

High-Density Vero Cell Perfusion Culture

High-Density Vero Cell Perfusion Culture

Content provided by Eppendorf Bioprocess Solutions | 01-May-2018 | Application Note

Viral diseases like rabies, rotavirus and influenza are causing many deaths worldwide, resulting in a strong demand for more productive manufacturing techniques...

Nifty Biosimilar

Nifty Biosimilar

Content provided by UGA Biopharma | 13-Mar-2018 | Research Study

Aflibercept (Zaltrap®) is a recombinant fusion protein with complex post-translational modifications. Therefore deep understanding of biosimilar development...

biopharma-reporter-image

Inline diafiltration enables continuous processing

Content provided by Pall Biotech | 13-Feb-2018 | Application Note

The Cadence inline diafiltration (ILDF) device is designed for continuous processing, in-process buffer exchange or contaminant removal in various processes...

Discover Fast and Simple Water Intrusion Testing

Discover Fast and Simple Water Intrusion Testing

Content provided by Pall Biotech | 13-Nov-2017 | Application Note

At Pall we have supported the water intrusion test for more than 20 years and we developed the Palltronic® AquaWIT IV system to deliver fast and simple...

The Next Stage – Eppendorfs new Mastercycler X50

The Next Stage – Eppendorfs new Mastercycler X50

Content provided by Eppendorf Bioprocess Solutions | 05-Sep-2017 | Application Note

The Mastercycler X50 is Eppendorf's new PCR cycler with lots of new benefits. Not only can you heat with 10°C/s, you can also optimize two different...

How to get reproducible DNA amplification

How to get reproducible DNA amplification

Content provided by Eppendorf Bioprocess Solutions | 27-Jun-2017 | Infographic

DNA concentration, mastermix preparation, temperature management: Doing PCR like a pro can be more complex than it seems.The Eppendorf infographic helps...

Scale-Up of Multicolumn Chromatography

Scale-Up of Multicolumn Chromatography

Content provided by Pall Biotech | 21-Jun-2017 | Application Note

The Cadence™ BioSMB platform from Pall Life Sciences is the first disposable flow path, continuous multicolumn chromatography solution that is fully scalable...

An Innovative Design for Single-use Bioreactors

An Innovative Design for Single-use Bioreactors

Content provided by Pall Biotech | 01-Jun-2017 | White Paper

For many years cylindrical stainless steel tanks have been used in biopharmaceutical production.The primary reason for the cylindrical shape was that it...

Engineering Performance: Single-Use Bioreactor

Engineering Performance: Single-Use Bioreactor

Content provided by Pall Biotech | 01-May-2017 | Application Note

Single-use bioreactors have only been cylindrical in design, until now. The Allegro™ STR single-use, stirred tank bioreactor provides advantages over the...

Automatic Fermentation with Auto Culture Mode

Automatic Fermentation with Auto Culture Mode

Content provided by Eppendorf Bioprocess Solutions | 10-Apr-2017 | Application Note

The Auto Culture modes, standard on the Eppendorf BioFlo® 120 bioprocess control station, offer push-button automatic process control for some of the most...

lyo_development

Best Practices in Formulation and Lyo Development

Content provided by Baxter BioPharma Solutions | 13-Feb-2017 | White Paper

The ultimate goal of formulation development is a stable product. In the case of a protein product, that can be defined as delivering the correct dose,...

Navigating Complex Biologics to Clinic Faster

Navigating Complex Biologics to Clinic Faster

Content provided by Catalent | 07-Nov-2016 | Infographic

With the increasing complexity of biologics and growing competition with players ranging from small start-ups to large pharma, an aggressive development...

Robust Virus Retention with Pressure Interruptions

Robust Virus Retention with Pressure Interruptions

Content provided by Pall Biotech | 17-Oct-2016 | Application Note

Virus filtration is a vital part of the viral clearance strategy in bioprocesses. In filtration, size exclusion mechanisms are orthogonal to other inactivation...

SGS-LSS

Functional Comparability of a Biosimilar

Content provided by SGS | 19-Sep-2016 | White Paper

Regulatory authorities require head-to-head comparison at multiple levels to demonstrate that a proposed biosimilar is “similar or highly similar” to the...

Continuous mAb Chromatography Process Optimization

Continuous mAb Chromatography Process Optimization

Content provided by Pall Biotech | 25-Jul-2016 | White Paper

Learn the advantages of transferring from single column to continuous chromatography processes with connected unit operations. This poster titled “Demonstration...

SGS-LSS-Detection-of-Mycoplasma-in-Biopharmaceuticals-EN-16

Mycoplasma Detection in Biopharmaceuticals

Content provided by SGS Life Science Services | 16-May-2016 | White Paper

The detection of mycoplasma contamination is of utmost concern in bio-therapeutic and vaccine manufacturing. The two pharmacopeia techniques rely on the...

Volume Reduction & Downstream Process Optimization

Volume Reduction & Downstream Process Optimization

Content provided by Pall Biotech | 04-Feb-2016 | Application Note

Pall’s single-pass tangential flow filtration (SPTFF) technology provides a simple solution for continuous concentration and optimization of DSP steps....

In search for “A cell line for Life”

In search for “A cell line for Life”

Content provided by Fujifilm Diosynth Biotechnologies | 23-Nov-2015 | White Paper

The key to developing an elegant, robust and manufacturing-ready process starts during cell line and process development. Early identification of the expression...

Infographic: How to become a pipetting expert

Infographic: How to become a pipetting expert

Content provided by Eppendorf Bioprocess Solutions | 09-Nov-2015 | Infographic

Reverse pipetting, problem liquids, getting the angle right: Pipetting like a pro can be more complex than it seems. The Eppendorf infographic helps you...

Screening for growth conditions using micro-Matrix

Screening for growth conditions using micro-Matrix

Content provided by Applikon Biotechnology | 12-Oct-2015 | Case Study

Screening of large number of cell lines, specific media or target drug could be tedious and expensive work. This is also the case for the characterization...

New White Paper: Multiplexing in Bioanalysis

New White Paper: Multiplexing in Bioanalysis

Content provided by SGS Life Science Services | 28-Sep-2015 | White Paper

SGS scientists have validated a multiplex, bead-based immunoassay which determines nine cytokines simultaneously per sample, resulting in savings in costs,...

A visual history of cold chain innovation

A visual history of cold chain innovation

Content provided by World Courier | 23-Jun-2015 | Infographic

Download World Courier’s latest piece which shares the story of the changes in temperature-controlled transport and what these trends mean to your business....

How Molded Manifold Assemblies Prevent Leaks

How Molded Manifold Assemblies Prevent Leaks

Content provided by AdvantaPure® | 22-Jun-2015 | White Paper

Pharmaceutical fluid transfer involves many tubing-to-fitting connections, and unfortunately those connections can leak and result in contamination, production...