Secondary antibodies for high-resolution imaging
Jackson ImmunoResearch, manufacturer of secondary antibodies and immunoreagents for the life science market, has announced a new range of detection reagents that the company says offer superior imaging quality.
“The single-domain antibody market is exploding; these antibodies are 1/10th the size of canonical immunoglobulins, making them ideal for drug delivery and super-resolution imaging, among many other potential uses,” commented David A Fancy, COO, Jackson ImmunoResearch.
The developer outlined how its Nano Secondaries are polyclonal VHH Fragment antibodies, available with specificity to Human, Rabbit, or Mouse, and10x smaller than conventional whole IgG antibodies.
“Polyclonal detection reagents continue to offer the best signal strength by amplifying signal, even from poorly expressing targets. Offering a heterogeneous population of antibodies, each detecting a different portion of the primary antibody, the polyclonal Nano Secondary can increase labeling efficiency, resulting in brighter signal. They are available conjugated to reporter enzymes and a range of fluorescent dyes, including Alexa Fluor, providing scope for high-resolution Immunohistochemistry and Immunofluorescence, making them an indispensable tool in both research and diagnostics imaging.”
Photo credit: Derek Sung, MD/PhD Student, University of Pennsylvania School of Medicine
