News & analysis on the clinical development and manufacture of large molecule drugs
Getting a better understanding of cellular immunity
By Jane Byrne
- Last updated on
Immudex ApS has been collaborating with Becton, Dickinson and Company (BD) to create improved solutions for T-cell multi-omics research.
That work led to the launch of dCODE Dextramer (RiO) reagents in February this year. These DNA barcoded MHC Dextramer reagents are designed to be compatible with the BD Rhapsody system to be used for multiplexing, allowing the identification of many different T-cell specificities in the same sample. Creating personalized dCODE Dextramer libraries, it is possible to profile T cells and get a new understanding of T-cell immunity, said the developer.
Liselotte Brix, CSO at Immudex, commented: “The immune system is complex, and there is still a lot to be discovered. dCODE Dextramer (RiO) technology combined with the BD Rhapsody single-cell multi-omic analysis provides a deeper understanding of T cell immunology in a user-friendly workflow by combining information on TCR recognition with gene and surface marker expression at the single-cell level. Such information helps unlock new insights into the immune response, accelerating basic research, immunotherapeutic development, and improving patient outcomes."