Sartorius creates vessel for its bioreactor system to improve scalability

By Maggie Lynch

- Last updated on GMT

(Image: Getty/Paket)
(Image: Getty/Paket)

Related tags Sartorius stedim biotech Sartorius bioreactor Single-use systems Single-use technology

Sartorius launches a new vessel for its ambr 250 modular bioreactor system to potentially accelerate cell and gene therapy process development and scale up into cGMP single-use bioreactors and bags.

The vessel is designed with a large pitched blade impeller and has a working volume of 100-250mL to provide an environment for mixing without sedimentation. Sartorius says this design enables optimal growth of single cell suspensions, cell aggregates or adherent cells on microcarriers.

Ian Ransome, head of product management and ambr multi-parallel systems at Sartorius, told us, “As cell and gene therapies evolve, and more clones and processes are created, different challenges are emerging, and the new vessels with the single impeller and no baffles offer a different environment for the culture of cells.”

Ambr 250 modular vessel
Ambr 250 modular vessel (Image: Sartorius Stedim)

He explained that the new vessel fits the evolution of cell and gene therapies, as it develops processes like adherent cell growth on microcarriers, T-cell culture, and process development for viral vector production.

According to Sartorius, the mini bioreactor has shown better cell culture performance in trials compared to a less predictive spinner or T-flask, enabling rapid process optimization and improved scalability.

Ransome explained that, as clinical demand rises, the need to scale up rather than scale out of particular process nodes will increase.

“In this context, applications such as viral vector production are increasingly shifting from adherent cell culture formats to the suspension format, which is very well catered for by scalable upstream production systems,”​ he said.

“Development tools such as ambr are playing their part in this transition, allowing teams to swiftly identify optimum conditions for suspension culture and adherent cultivation on microcarriers.”



Related topics Upstream Processing

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