MilliporeSigma adds first non-mammalian cell line to portfolio

By Maggie Lynch contact

- Last updated on GMT

(Image: Getty/Cast08)
(Image: Getty/Cast08)

Related tags: Cell line, Cell line development, Vaccine, Gene therapy, Virus

MilliporeSigma collaborates with GlycoBac to provide an Sf-9 insect cell line for vaccine and gene therapy development.

GlycoBac, a biotechnology company that spun-out of the University of Wyoming, will provide its rhabdovirus-negative (RVN) cell line to allow MilliporeSigma, a contract development and manufacturing organization (CDMO) to offer the first Sf-9 platform in combination with a rhabdovirus-free insect cell line to provide a streamlined insect cell line production. The cell line will also have a corresponding chemically defined cell culture medium.

Nikolai Stankiewicz, global product manager of cell culture media and biopharma materials at MilliporeSigma, told us that this Sf-rhabdovirus-negative cell line will accelerate the biomanufacturing processes by eliminating the time needed to remove the rhabdovirus, which is necessary for traditional processes. Rhabdovirus is a process contaminant that clients often have to remove for the safety of the cell line.

This platform will be the first non-mammalian cell line in MilliporeSigma’s cell culture portfolio. With this addition, the company’s clients will have access to a vehicle for recombinant protein expression, virus-like particle vaccines and adeno-associated virus (AAV)-based gene therapy production.

According to Stankiewicz, the Sf-RVN cell line and an additional ex-cell CD-insect medium platform prototype are currently being evaluated by partners focusing on AAV production to meet the demands of commercial-scale production. The new platform is capable of producing all therapeutic classes that are traditionally manufactured with insect cells.

Related news

Related products

show more

How Viral Safety Testing Will Evolve

How Viral Safety Testing Will Evolve

Viral Safety for mAb: Prevent, Detect, Remove | 20-May-2020 | Event Programme

The pressure to shorten delivery times and reduce costs for biologics are driving an evolution in the biomanufacturing space. Many of the methods used...

rAAV Production in BioBLU® Single-Use Vessels

rAAV Production in BioBLU® Single-Use Vessels

Eppendorf for Bioprocess – Solutions that grow with you | 25-Jun-2019 | Application Note

Rising interest in gene therapy-based applications leads to increasing demands in scalable production systems for viral vectors. Find out how Cevec Pharmaceuticals...

Small-Scale Cell Culture Perfusion Process

Small-Scale Cell Culture Perfusion Process

Eppendorf for Bioprocess – Solutions that grow with you | 29-Mar-2019 | Application Note

Perfusion cell culture processes promise advantages for industrial bioprocessing, like saving space, increasing volumetric productivity, achieving more...

Cultivation of 3D Cell Aggregates in Perfusion

Cultivation of 3D Cell Aggregates in Perfusion

Eppendorf for Bioprocess – Solutions that grow with you | 17-Sep-2018 | Application Note

3D cell aggregates are of great interest for applications like disease modeling and manufacturing of stem cell-based products. Read more about the cultivation...

Related suppliers

Follow us

Products

View more

Webinars