Pall lands WuXi fit out for mAb continuous bioprocess lab

By Flora Southey contact

- Last updated on GMT


Related tags: Wuxi biologics, Biotechnology, Monoclonal antibodies

Pall Corporation will equip WuXi Biologics’ continuous bioprocess laboratory in Shanghai, China, which the latter said would expand process scale and reduce manufacturing costs.

US-headquartered Pall will equip the laboratory with its Cadence Integrated Continuous Bioprocess System and single-use technology platform to make monoclonal antibodies (mAb) at the site.

“Pall has the most advanced technology in continuous processing technology,” ​a WuXi Biologics spokesperson told us.

The project launched yesterday, and will initially focus on individual processes.

China-headquartered WuXi Biologics said the project will “gradually be expanded to downstream processing development and production.”

The laboratory will help the firms jointly enhance large-scale purification equipment and technology for the continuous process, added Wuxi Biologics.

The spokesperson told us 60 staff members will be assigned to the project, which will include 20 new positions at the laboratory.

Scale up, cost down

WuXi Biologics said the continuous process could significantly reduce mAb drugs’ manufacturing costs.

The contract development and manufacturing organisation (CDMO) said it had developed high-yielding cell lines and laboratory-scale continuous processes, ‘significantly increasing the expression of some mAbs to up to equivalent of 40-50 g/L in the traditional fed-batch process, which is approximately 10 times more productive than the typical fed-batch process.”

WuXi Biologics said it plans to expand the continuous process scale to 500 L and reduce mAb manufacturing cost to 30-50 USD/g.

From there, the firm said it hopes to “reduce mAb manufacturing cost to 30-50 USD/g, and then scale up to 1000 L and further reduce costs to less than 15 USD/g.”

Earlier this year​, WuXi Biologics announced Thermo Fisher Scientific would supply single-use technologies at its Wuxi City, China-based mammalian cell culture manufacturing site.

Related news

Show more

Related products

show more

Discover the world of upstream bioprocessing

Discover the world of upstream bioprocessing

Eppendorf Bioprocess Solutions | 07-Sep-2022 | Technical / White Paper

A must-read for all bioprocess scientists: This bundle of four ebooks created by Eppendorf guides you through the world of upstream bioprocessing.

dPCR Case Study

dPCR Case Study

CellCarta | 08-Aug-2022 | Case Study

Streamline your adoptive cell therapy program with digital PCR. Our team has a unique expertise in digital and quantitative PCR to support you in ensuring...

The Reagents Behind Much of Molecular Biology

The Reagents Behind Much of Molecular Biology

Thermo Fisher Scientific | 25-Jul-2022 | Case Study

The ability to amplify, modify and fabricate DNA is fundamental to modern molecular biology. Why do so many researchers take their constituent parts for...

Microsampling in Early Phase Drug Development

Microsampling in Early Phase Drug Development

Altasciences | 10-May-2022 | Technical / White Paper

Microsampling significantly lessens the volume of blood and plasma/serum that is collected and analyzed to determine circulating concentrations of therapeutic...

Related suppliers

Follow us


View more