Aska buys option to commercialize Pieris' potential EPO rival in Japan

By Gareth Macdonald contact

- Last updated on GMT

iStock/bedo
iStock/bedo

Related tags: Erythropoietin

Aska Pharmaceutical Co. Ltd has bought an option to commercialize Pieris Pharmaceuticals’ anaemia candidate and EPO rival, PRS-080, in Japan.

The deal​ grants Aska the option to develop and commercialize the drug in Japan and other Asian markets.

Pieris was paid $2.75m (€2.59m) upfront for the option and stands to earn more than $80m in developmental and regulatory milestones if the option is exercised.

PRS-080 is a modified lipocalin protein that inhibits hepcidin, a polypeptide regulator of the iron metabolism. An excess of the protein in patients with kidney disease prevents iron uptake.

The idea is that PRS-080 is used to treat anaemia in kidney disease patients an alternative to current therapies like high dose erythropoietin stimulating medicines. 

A spokesman for Pieris told us PRS-080 is “produced in a high-quality E. coli expression system, which is cheaper than mammalian production​” adding the drug "is subsequently PEGylated for half-life extension​.”

CMO supply

At present PRS-080 is made on Pieris’ behalf by an unnamed contract manufacturing organisation (CMO). The contractor is likely to be supply Aska in the short term according to the spokesman.

Aska and Pieris will negotiate future supply arrangements during the ASKA option period but ASKA will be responsible for all costs related to drug supply in its territory and will also be responsible for its own market supply​” he said.

Pieris has completed dosing in a Phase Ib study​ in CKD patients on hemodialysis and will pursue a multi-dose, Phase IIa study in the same population, in the second half of 2017.

Related news

Related products

show more

How Viral Safety Testing Will Evolve

How Viral Safety Testing Will Evolve

Viral Safety for mAb: Prevent, Detect, Remove | 20-May-2020 | Event Programme

The pressure to shorten delivery times and reduce costs for biologics are driving an evolution in the biomanufacturing space. Many of the methods used...

Protect your bulk filtration and dispense step

Protect your bulk filtration and dispense step

Parker Bioscience Filtration | 20-Jan-2020 | Data Sheet

Does your process need greater protection when the value of your product is at its highest?

At the bulk filtration and container fill stage,...

rAAV Production in BioBLU® Single-Use Vessels

rAAV Production in BioBLU® Single-Use Vessels

Eppendorf for Bioprocess – Solutions that grow with you | 25-Jun-2019 | Application Note

Rising interest in gene therapy-based applications leads to increasing demands in scalable production systems for viral vectors. Find out how Cevec Pharmaceuticals...

Related suppliers

Follow us

Products

View more

Webinars