Stem Cell Theranostics secures "freedom to operate" in IP deal with GE Healthcare

By Gareth Macdonald contact

- Last updated on GMT

Related tags: Ge healthcare, Stem cell

Stem Cell Theranostics' headquarters in California, US
Stem Cell Theranostics' headquarters in California, US
Stem Cell Theranostics has secured rights to the technology it uses to make cellular heart disease models for drug development through a deal with GE Healthcare.

Stem Cell Theranostics announced the sub-license with GE Healthcare last night, explaining that the agreement covers intellectual property (IP) needed to generate human cardiomyocyte models for preclinical drug development from induced pluripotent stem cells (iPS).

Spokeswoman Rachel Bolger told us the deal “ensures that we and our partners have the appropriate freedom to operate,” ​adding that the firm will use the GE Healthcare IP in combination with cells from a biobank operated by the Stanford Cardiovascular Institute.

Using this biobank, we are able to generate a library of cardiomyocytes disease models that harbour genetic mutations that cause hypertrophic cardiomyopathy, dilated cardiomyopathy and various channelopathies.

These patient-derived cardiomyocytes exhibit a variety of disease phenotypes including hypertrophy, contraction defects and arrhythmias, making them attractive disease models for drug efficacy and toxicity testing.

She added that: “While other organizations have commercialized normal cardiomyocytes, we are currently the only commercial company that is focusing on genetic disease models for heart failure.”

Sub license

The IP was originally developed by Geron.

GE Healthcare licensed it in 2009 according to a company spokeswoman who explained that: "In 2012 GE expanded this agreement obtaining exclusive global rights to Geron’s IP for the development and sale of cellular assays derived from iPS cells."

GE Healthcare licensed the same IP to Cellular Dynamics in 2012. 

IP licensing

Heart disease models developed by Stem Cell Theranostics are already being used by the firm for its internal drug development programmes and by partners seeking to identify novel disease mechanisms and drug targets Bolger said.

The GE license follows just four months after the firm signed a non-exclusive deal to access knowhow developed by IPS Academia Japan.

Like the new accord, the earlier agreement covered use of IP to generate drug discovery models from cells obtained from a biobank, specifically one operated by Kyoto University’s Center for iPS Cell Research and Application.

Related news

Show more

Related products

show more

rAAV Production in BioBLU® Single-Use Vessels

rAAV Production in BioBLU® Single-Use Vessels

Eppendorf for Bioprocess – Solutions that grow with you | 25-Jun-2019 | Application Note

Rising interest in gene therapy-based applications leads to increasing demands in scalable production systems for viral vectors. Find out how Cevec Pharmaceuticals...

Small-Scale Cell Culture Perfusion Process

Small-Scale Cell Culture Perfusion Process

Eppendorf for Bioprocess – Solutions that grow with you | 29-Mar-2019 | Application Note

Perfusion cell culture processes promise advantages for industrial bioprocessing, like saving space, increasing volumetric productivity, achieving more...

Cultivation of 3D Cell Aggregates in Perfusion

Cultivation of 3D Cell Aggregates in Perfusion

Eppendorf for Bioprocess – Solutions that grow with you | 17-Sep-2018 | Application Note

3D cell aggregates are of great interest for applications like disease modeling and manufacturing of stem cell-based products. Read more about the cultivation...

Related suppliers

Follow us

Products

View more

Webinars