B-MS extends biologics manufacturing contract with Lonza

By Zachary Brennan

- Last updated on GMT

The extension adds a second biologic to Lonza's manufacturing contract
The extension adds a second biologic to Lonza's manufacturing contract

Related tags Lonza Bristol-myers squibb

Bristol-Myers Squibb (B-MS) and Lonza on Thursday announced a multi-year expansion of their existing biologics manufacturing agreement. 

The contract, which began in 2003, will be expanded to include the production of commercial quantities of a second unnamed B-MS biologic medicine at Lonza’s mammalian manufacturing facility in Portsmouth, New Hampshire. Financial terms of the agreement were not disclosed.

A B-MS spokesman told BioPharma-Reporter.com that Lonza currently manufactures the active drug ingredient for rheumatoid arthritis treatment Orencia (abatacept) in Portsmouth. Lonza also currently produces clinical supplies of an investigational biologics medicine for B-MS.

 “Our expanded relationship with Lonza is an important example of our global manufacturing strategy to meet anticipated demand for our commercial biologics portfolio and prepare to bring our late-stage clinical assets to patients by supplementing our in-house manufacturing capabilities​,” said Lou Schmukler, President, Global Manufacturing & Supply, B-MS.

B-MS is also increasing its own manufacturing capacity in order to meet current and future demand for its biologics.

With several potential new biologics in our R&D pipeline, we are prudently increasing our biologic manufacturing capacity now in order to help ensure sufficient, long-term supply of our current and future biologic products​,” a B-MS spokesman told us. “This is not a question of capabilities but rather increasing our capacity​.”

B-MS previously selected Samsung Biologics in a 10-year deal to manufacture​ its monoclonal antibody Yervoy for markets outside the US. The companies later expanded that relationship​ to include other unnamed biologics.


In addition to its state- Portsmouth facility, Lonza offers three additional clinical-to-commercial mammalian production facilities in Tuas, Singapore; Porrino, Spain; and Slough, United Kingdom.

Questions were raised​ on whether Lonza would be able to fill its manufacturing capacity after a biosimilar JV with Teva fell through, though Lonza said it remained confident.

"We are pleased to extend our relationship with Bristol-Myers Squibb for the commercial production of their innovative drug-substance​,” said Marc Funk, COO of Lonza’s Pharma & Biotech Segment. “This reinforces Lonza’s mission to support life-saving medicines by being a reliable supplier of Active Pharmaceutical Ingredients (APIs) for our customers with high-quality  commercial GMP manufacturing services delivered to the market​.”

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