dispatches from bioprocess international

Pall, Thermo Scientific, Fujifilm, Merck Millipore unveil new upstream, downstream offerings

By Zachary Brennan contact

- Last updated on GMT

New techs showcased in Boston
New techs showcased in Boston

Related tags: Cell culture, Biotechnology

The products, unveiled at BioProcess International in Boston this week, will help industry with their upstream and downstream processing and include an anti-CHO host cell protein detection kit, the first single-use fermentor, and a new mammalian expression platform.

Pall announced the commercial availability of its new Dip and Read Anti-CHO (Chinese hamster ovary) Host Cell Protein (HCP) Detection Kit for quantitation of residual HCPs. Kit users will benefit from faster time to results, enhanced range of detection and better assay precision. The kit can also be applied in production phases to confirm reduction or removal of HCP, increasing efficiency and speed of production.

Ian Sellick, director of marketing at Pall, told us the launch of the kit was set up in order to coincide with the conference, noting the design allows the analysis to be done in about an hour. 

The kit combines the Pall ForteBio Octet platform for rapid high-throughput protein analysis with the broad HCP recognition and sensitivity of the industry-standard Cygnus 3G anti-CHO HCP antibody. The high-precision assays have 5-10% CVs, and the.  

The commonly used ELISA HCP analytical method can require up to overnight analysis and must be monitored. Our new Dip and Read high-precision assay kit, in combination with the Octet HTX system, is hands-free, and only takes around an hour to analyze 96 samples with detection sensitivity as low as 0.5 ng/mL​,” said Yves Baratelli, President of Pall Life Sciences.

Six of the kits were used in beta testing and the company said it received positive feedback, Sellick told us.

Thermo

Meanwhile, Thermo Scientific unveiled three new products, including the HyPerforma Single-Use Fermentor, which it claims is the first single-use system specifically engineered for microbial fermentation. The fermentor is designed to support scale up and GMP production, and can integrate into existing Thermo Scientific single-use technologies.

Product manager Daniel Nelson told us the creation of the fermentor was driven by industry demand.

The company also launched Gibco EfficientFeed A+, B+ and C+ supplements, which are meant to optimize cell culture manufacturing to provide a nutrient delivery technology to super-concentrate feeding supplements for optimal cell culture manufacturing. This improvement in bioreactor space utilization enables commercial laboratories the ability to reduce product dilution, maximize working volume and increase product titers up to 120 percent.

In addition, the company launched its new POROS XQ Chromatography Resin, which is a high-capacity, high-resolution, salt-tolerant strong anion exchange (AEX) resin. The resin offers superior product yield, fewer cycles and greater flexibility in bind and elute or flow-through modes of chromatography to optimize downstream processing.

Fujifilm

Alison Porter, head of mammalian cell culture R&D at Fujifilm Diosynth, also unveiled its CHO DG 44-derived mammalian expression platform.

The platform promises to deliver transfection to RCB in 25 weeks and enables improved and early prediction of the best cell lines to progress. She noted that the material supply is scalable from shake-flasks to a 10L rocking bioreactor to a 200L Xcellerex XDR bioreactor.

The platform also offers an animal-component-free media and new screening technologies.

Merck Millipore

Merck Millipore also launched three new chromatography resins for its Chromabolt​prepacked columns. The pre-validated chromatography columns – which are available in three sizes, 10cm, 20cm and 32cm inner diameter -- can come packed with either strong cation exchangers, weak cation exchangers or strong anion exchangers.

The company also released a new film used in the construction of Mobius single-use process containers for biopharmaceutical manufacturing. The film’s rugged outer layer offers strong resistance to leak formation.

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