Which came first the spaniel or the egg? Novartis' flu vaccine plant OKed

By Gareth Macdonald

- Last updated on GMT

Cocker spaniel-derived MDCK cells key to winter influenza vaccine supplies
Cocker spaniel-derived MDCK cells key to winter influenza vaccine supplies

Related tags Influenza vaccine Influenza

A long dead cocker spaniel will play a key role in helping people avoid the flu this winter after a landmark approval from the US FDA for Novartis’ cell culture based vaccine plant.

Which came first - the spaniel or the egg?

If we are talking about influenza vaccine production then the answer is definitely egg. Hens’ eggs have been used for this purpose since shortly after Woodruff and Goodpasture discovered they could be used for viral culturing in 1931​.

But, if the question is “which plays the most important role in flu vaccine production: the spaniel; or the egg?”,  the answer could soon be ‘spaniel’ after Novartis was licensed to start making seasonal influenza vaccine at its cell culture plant in Holly Springs, North Carolina this week.

The Swiss drugmaker manufacturers its vaccines using Madin-Darby Canine Kidney (MDCK) cells derived from a female cocker spaniel in 1958​, which provide for a much simpler and more reliable production process according to spokeswoman Elizabeth Power.

Traditional influenza vaccine production depends on a large number of fertilized chicken eggs to grow virus strains and requires many months for organization of egg supplies, virus incubation and actual production before the vaccine is delivered to physicians or pharmacies.”

Cell-culture manufacturing technology is an alternative production method to traditional egg-based production. Cell-culture technology utilizes a well-characterized mammalian cell line rather than chicken eggs to grow virus strains​” Power continued.

She went on to tell BioPharma-Reporter.com that while the facility was already producing trial supplies of Novartis’ Flucelvax and adjuvants used in other products “the FDA licensure means that Holly Springs will produce seasonal flu vaccine for the 2014-2015 flu season​.” 

Novartis was contracted​ to develop the Holly Springs site​ for cell-culture vaccine production in 2007 by the US Department of Health and Human Services (HHS) as part of both the US’ seasonal vaccine production efforts and its pandemic preparedness programme.  

Power explained that: “As part of its contract with the US government, the site has also developed and tested vaccines and manufactured bulk stockpiles of antigens and adjuvants for pandemic threats, including H7N9 influenza, which emerged in 2013​.”

Related news

Show more

Related products

show more

Trends in Biopharmaceutical Raw Material Selection

Trends in Biopharmaceutical Raw Material Selection

Actylis – The Partner of Choice | 31-Jan-2023 | Business Advice

Join us as our in-house experts, along with Cecile Bellamy from Pfizer, discuss current and future trends in biopharmaceutical raw material selection.

Liposomal and Nanoparticle Technology

Liposomal and Nanoparticle Technology

Pfizer CentreOne | 18-Nov-2022 | Technical / White Paper

Medical science is continuously searching for better ways to administer drugs into the body and to maximize the therapeutic effectiveness of the drugs...

Connectivity & Integration in Biomanufacturing

Connectivity & Integration in Biomanufacturing

Wheeler Bio | 17-Nov-2022 | Technical / White Paper

As the Pharma 4.0 initiative sets a new industry paradigm, more biomanufacturing companies are asking how they can design and build facilities that apply...

Scalability, Quality, and Speed with Transposons

Scalability, Quality, and Speed with Transposons

Wheeler Bio | 20-Oct-2022 | Technical / White Paper

To solve for the significant bottlenecks often presented by conventional cell line development processes, this article discusses how Wheeler Bio is leveraging...

Related suppliers

Follow us

Products

View more

Webinars