Continuous chromatography tech part of 'facility of the future,' says Novasep

By Dan Stanton contact

- Last updated on GMT

Related tags: Chromatography, High performance liquid chromatography, Novasep

Novasep riding on downstream tech and services in 2013
Novasep riding on downstream tech and services in 2013
Novasep has reported a 14 percent growth in its biopharma business driven in part by demand for downstream manufacturing and its continuous chromatography systems.

For the full year ending December 31 2013, the France-headquartered firm reported an 8% growth in revenue, to €316m ($436m) across all businesses. However, for its biopharma business, Novasep recorded a 14% surge to €52.5m driven by sales of bioprocessing equipment and an increase in contracts for its biomanufacturing services.

One area the firm has seen a specific increased demand for is its downstream processing technologies, particularly its BioSC continuous chromatography solution for the purification of monoclonal antibodies (mAbs), blood fractions and proteins.

“This technology, which provides a stepwise improvement in resin and buffer consumption, is gaining acceptance on the market place in particular for large volume applications,”​ Michel Spagnol, Novasep CEO told “We believe it will be a central component of the so-called 'facility of the future' in the biopharma industry.”

Whilst he said Novasep worked with a broad range of companies – from emerging biotechs to big biopharma – it is “the current surge in financing opportunities in the biotech sector” ​that has led to “more of the emerging players coming [Novasep’s] way.”

Elsewhere in its downstream offerings, Spagnol told us the company’s AbSolute High Cap protein A media and its Sius fully disposable tangential flow filtration technology were “the most competitive on the market,”​ boosting growth further, whilst its high-performance liquid chromatography (HPLC) systems were topsellers last year.


We also asked Spagnol about the firm’s antibody-drug conjugate (ADCs) services, following a €3m investment in 2012​ at its Le Mans, France facility, and in light of heavy investment from other contract manufacturing organisations since (Catalent​, ADC Bio​, Carbogen Amcis​ to name three).

“Novasep has upstream and downstream biomanufacturing operations for producing monoclonal antibodies under cGMP conditions,”​ he said, adding it also had a twenty-year track record in cytotoxic API and payload production at Le Mans.

“We not only have the expertise in safely handling such active compounds but we also have a wide experience in synthesizing almost all chemical families of payloads, with enabling know-how and technology in purification, allowing us to reach very high yields and minimize production costs.”

He continued: “Additionally, we are among the few companies in the world mith more than 5 years of experience in conjugation at small scale that we are now ready to expand to meet market expectations.”

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