news from Biotechnica

New Pall single-use TFF tech attracts attention

By Gareth Macdonald

- Last updated on GMT

New Pall single-use TFF tech attracts attention
New Pall single-use TFF tech attracts attention
A new filter tech developed by Pall Life Sciences attracted a lot of attention at the Biotechnica trade show in Germany this week with some attendees describing it as the industry's first truly ‘single-use’ TFF module.

The majority of ‘single-use’ tangential flow filtration (TFF) modules currently on the market are composed of disposable filtration cassettes that are held in place by - definitively non-disposable - stainless steel supports that need cleaning each time the filter is discarded.

The innovative feature of Pall’s new line of Cadence single-use tangential flow filtration (TFF) modules – which were showcased in Hanover this week – is that the cassettes are held in mounts that can be disposed of when the filter is changed.

Pall says that the filters – which are supplied gamma irradiated – are easier to install than other TFF modules currently on the market and that they reduce downtime, validation requirements and post-use conditioning steps.

The word cadence means rhythmic flow and is usually applied to poetry or speech, which is somewhat ironic given that Pall declined to comment when asked for more details about the technology and its intended market during our visit to Biotechnica.

In an emailed response to the firm said: “Cadence single-use TFF modules can be easily implemented in single-use TFF systems for concentration and diafiltration steps from R&D to commercial production of biotech products or vaccines."

Other Biotechnica attendees who spoke with were more willing to talk about Pall’s technology.

One representative of a rival biomanufacturing systems supplier –who tipped us off about the technology in the first place but asked not to be named - described the system as the industry’s first “truly single-use TFF module​.”

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