New depth filter released

By Katrina Megget

- Last updated on GMT

Related tags: Disposable

US-based Pall Corporation has launched a new depth filter which is
disposable and can be scalable from personalized medicine
applications to large scale commercial use.

The SupraCap 100 depth filter capsule is the only intermediate-scale depth filter to be offered in a range of sizes, styles and configurations which removes and clarifies a large volume of contaminant from process streams. Made from four main components - cellulose fibers, diatomaceous earth, naturally occurring volcanic ash known as perlite, and resins - the SupraCap 100 is able to remove particles by a combination of absorption and size exclusion within its porous matrix rather than on its frontal surface and do so for batch sizes from five liters to more than 100 liters in size. "Now with the new SupraCap 100 capsules, end users have the ability to use the same depth filter technology from the very small scale through to clinical and commercial scale,"​ Pall Life Sciences global product manager Scott Anderson told US-PharmaTechnologist.com. "In the past, many end-users were resigned to using any filters they might have available to purify the products they are making when working at these small scales. Traditionally little thought was put into scalability, performance and cost in producing these small quantities but now as budgets are tightening, early stage process validation is more common and process development time lines are shortening, the use of fully scalable products at very small scale through to commercial are now very important." ​ Anderson said SupraCap provided a link between discovery and production processes. The depth filter was also disposable meaning that cleaning and cleaning validation was no longer needed, which saved time in the process. "Another major aspect to using disposable products is the elimination of possible cross contamination from batch to batch or product to product due to poor cleaning procedures. For many end-users disposable technology is the best choice, allowing them to utilize one facility to produce multiple products as the filters and processing equipment in direct product contact are all disposable,"​ Anderson said. The SupraCap 100 utilizes an existing capsule design that has been well accepted by the biopharma industry as the Kleenpak Nova, he said. The depth filter can be manifolded together or connected upstream of the Kleenpak Nova filters to create a complete disposable filter train. To maximize processing flexibility, the new SupraCap 100 depth filter capsule is available in single or double-layer media in 10, 20 and 30 inches lengths with either in-line or T-style configurations. By supporting both the upstream and downstream side of each depth filter sheet with an outside and inside separator plate, the new depth filter capsule design prevents lost product batches caused by high pressure blow-outs and ensures that the system will not fail under changing pressure conditions. Anderson said the filter was easy to install as it was available with a variety of different end fittings.

Related topics: Upstream Processing

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