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Single-use bioreactors: 2,000L a ceiling, says new BPSA board member

17-Jan-2017 - The majority of biomanufacturers use single-use systems at least in the development stage says Entegris’ Eric Isberg, but scaling-up will always be a problem.

AGC boasts 44,000L of biomanufacturing capacity on back of recent M&A

11-Jan-2017 - After buying two CMOs, Japanese glassmaker AGC has made “a full-fledged launch” into the biologics manufacturing space and says it will consider further M&A opportunities.

Shire selling Baxalta site in Austria once earmarked to make hemophilia drug

06-Jan-2017 - Shire has confirmed it is selling a former Baxalta manufacturing site in Austria once earmarked for a €138m ($145m) expansion and modernisation.

Synpromics to develop synthetic promotors for GE’s CHO platform

04-Jan-2017 - GE Healthcare hopes to increase the yield of biopharmaceuticals made using its Chinese Hamster Ovary (CHO) expression system through a partnership with synthetic biology firm Synpromics.

Wacker adding cysteine capacity through Spanish acquisition

21-Dec-2016 - Wacker says it is buying a large-scale fermentation facility in Spain to support growing demand for the amino acid cysteine.

Catalent’s CHO cell lines and Gate’s Foundation to make PATH Malaria vaccine

21-Dec-2016 - Catalent has partnered with US non-profit PATH for antibody discovery using the CDMO’s GPEx cell line platform, funded by PATH’s Malaria Vaccine Initiative (MVI).

Oxford genetics secures $2m for bioproduction optimisation R&D

21-Dec-2016 - Oxford Genetics hopes to provide improved bioinformatics in order to optimise mammalian bioproduction through a £1.6m grant.

AGC expanding CDMO biz through $500m CMC Biologics buy

21-Dec-2016 - AGC Asahi Glass has signed an agreement to buy CMC Biologics, the second biologics CDMO acquisition for the Japanese chemicals firm in three months.

DuPont gets Gates grant for protein drug production platform

20-Dec-2016 - DuPont has joined a Gates Foundation backed effort to develop low cost production methods for therapeutic proteins.

Univercells part of Gates-backed group trying to cut polio vaccine cost

16-Dec-2016 - The Bill & Melinda Gates Foundation has granted Univercells $12m (€12.5m) to develop a vaccine manufacturing platform that lowers production costs.

BMS reshuffles US operations with multiple R&D closures and construction

14-Dec-2016 - Bristol-Myers Squibb has announced plans to pull the plug on some US facilities and streamline construction and investment around “vibrant academic ecosystems”. 

Avid on track for third plant and to clear $73m biomanufacturing backlog

13-Dec-2016 - Avid Bioservices has reported strong contract manufacturing revenues for its Q2 and is confident a planned third facility will not leave the firm with too much capacity.

MilliporeSigma to speed up production of Acticor’s antibody against stroke

07-Dec-2016 - Acticor Biotech has made a deal with Merck KGaA’s CMO MilliporeSigma to use its Provantage End-to-End services to make its anti-thrombotic antibody fragment ACT-017 for stroke.

French connection: Vaccine biomanufacturing service providers Accinov and Biodextris merge

05-Dec-2016 - Accinov has teamed up with Canadian clinical research organisation (CRO) Biodextris to provide a transatlantic biomanufacturing ‘plug and play’ service for biopharmaceuticals—with a particular expertise in vaccines.

Valitacell moves into NIBRT lab space to further develop cell lines

02-Dec-2016 - Valitacell has moved into the National Institute for Bioprocessing Research and Training (NIBRT) as it works to further develop its cell performance technologies.

Breaking the Big Four: vaccine oligopoly unlikely to be challenged, analyst

02-Dec-2016 - Long lead times and high barriers to entry will restrict competition in the vaccines market, leaving GSK, Sanofi, Merck & Co. and Pfizer dominant, a Jefferies analyst says.

Takeda building Dengue fever vaccine plant

01-Dec-2016 - Takeda has started work on a vaccine plant to make its candidate Dengue fever virus vaccine, TAK-003.

WuXi to make Prima proteins from new 28,000L single-use facility in China

29-Nov-2016 - WuXi Biologics will make a recombinant soluble LAG-3 protein on behalf of Prima Biomed from its 28,000L single-use facility in China set to open next year.

Pfizer axes parts of $425m Irish expansion after dropping PCSK9 inhibitor

28-Nov-2016 - Plans to build a five-story biomanufacturing plant in Ireland could be shelved following the clinical failure of Pfizer's proposed cholesterol-lowering candidate bococizumab.

Oxford Genetics to address viral vector scalability with Innovate UK grant

22-Nov-2016 - Oxford Genetics is looking to overcome the inefficient and costly scale-up of viral vector production through a $1m grant to develop new cell lines.

One down, five to go: Autolus takes space at UK cell & gene therapy centre

22-Nov-2016 - T-cell immunotherapy firm Autolus has become the first tenant at the Cell and Gene Therapy (CGT) Catapult manufacturing facility in the UK.

Mylan boasts of 16 biosimilars in portfolio after Mabion rituximab deal

11-Nov-2016 - Mylan has struck a deal to commercialise a version of Roche’s Mabthera in Europe made by Polish biotech Mabion using a 2,500L disposable bioreactor system.

update

Keryx names Patheon as second Auryxia contractor

10-Nov-2016 - Keryx Biopharmaceuticals has hired Patheon to make the kidney disease drug Auryxia (ferric citrate) after its original contractor halted production.

Rentschler ups capacity again, with second 2,000L single-use bioreactor

08-Nov-2016 - Biologics CMO Rentschler has increased its single-use capacity by 50%, just weeks after opening a stainless steel facility at its site in Germany.

Media partners: GE and Valneva boost for vaccines made using EB66 cell line

08-Nov-2016 - GE Healthcare and Valneva have developed a cell culture media they say reduced batch variability when producing viruses from the EB66 cell line.

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